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学科主题: 临床医学
题名:
Quantification of cerebral blood flow by flow-sensitive alternating inversion recovery exempting separate T1 measurement in healthy volunteers
作者: Xiao Jiang-xi; Zhang Xue-hui; Xie Sheng; Zou Run-lei
关键词: arterial spin labeling ; cerebral blood flow ; perfusion
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2006-12-20
卷: 119, 期:24, 页:2096-2100
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: FAIR TECHNIQUE ; PERFUSION ; MULTISLICE ; VALIDATION
英文摘要:

Background The feasibility of the mapping of quantitative cerebral blood flow (CBF) named flow-sensitive alternating inversion recovery exempting separate T1 measurement (FAIREST) is still controversial. This study aimed to evaluate the reliability of FAIREST in the measurement of regional CBF (rCBF) in healthy volunteers.

Methods Eighteen healthy volunteers underwent magnetic resonance (MR) scanning with the sequence of FAIREST. While they were at rest, rCBF values were obtained in various brain regions of interest (ROIs). The same scheme was repeated on every subject after two weeks. Statistical analysis was made to determine the effect of location, scan and side on the measurement of rCBF.

Results The mean CBF values were (122 +/- 28) ml center dot (100 g)(-1) center dot min(-1) and (43 +/- 10) ml center dot (100 g)(-1) min in the gray and white matter respectively. There was significant main effect of location (t=-12.5, P < 0.01), but no significant effect of side. Paired t-test of ROIs in the same slice showed no significant difference in most sites between two scans, except in the gray matter of the bilateral frontal lobes (t=2.18 - 2.34, P < 0.05). However, the rCBF values of the same structure obtained from different slices showed a significant difference (t=-3.49, P < 0.01).

Conclusion FAIREST is a reliable technique in the measurement of rCBF, but different imaging slice may affect the agreement of rCBF across the scans.

语种: 英语
WOS记录号: WOS:000243090400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63093
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
2.Peking Univ, Inst Phys, Beijing 100870, Peoples R China

Recommended Citation:
Xiao Jiang-xi,Zhang Xue-hui,Xie Sheng,et al. Quantification of cerebral blood flow by flow-sensitive alternating inversion recovery exempting separate T1 measurement in healthy volunteers[J]. CHINESE MEDICAL JOURNAL,2006,119(24):2096-2100.
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