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学科主题: 临床医学
题名:
A novel glucose colorimetric sensor based on intrinsic peroxidase-like activity of C-60-carboxyfullerenes
作者: Li, Ruimin1; Zhen, Mingming1; Guan, Mirong1; Chen, Daiqin1; Zhang, Guoqiang1; Ge, Jiechao2; Gong, Ping3; Wang, Chunru1; Shu, Chunying1
关键词: C-60-carboxyfullerenes ; Peroxidase-like activity ; Colorimetric sensor ; Glucose
刊名: BIOSENSORS & BIOELECTRONICS
发表日期: 2013-09-15
DOI: 10.1016/j.bios.2013.03.057
卷: 47, 页:502-507
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
研究领域[WOS]: Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
关键词[WOS]: MAGNETIC NANOPARTICLES ; GRAPHENE OXIDE ; URINE GLUCOSE ; FULLERENE ; VISUALIZATION ; BIOCATALYSIS ; DERIVATIVES ; MIMETICS ; CHITOSAN ; ACID
英文摘要:

C-60-carboxyfullerene, C-60[C(COOH)(2)](2), has been proven to function as peroxidase mimetics that can catalyze the reaction of peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H2O2 to produce a blue color reaction. Kinetic studies further indicate that C-60[C(COOH)(2)](2) has an even higher affinity to TMB than that of the natural enzyme, horseradish peroxidase (HRP). C-60[C(COOH)(2)](2)/glucose oxidase (GO(x))/TMB system provides a novel colorimetric sensor for glucose and shows good response toward glucose detection over a range of 1.0-40 mu M with a limit of detection 0.5 mu M (3 sigma/slope). Moreover, this sensitive and selective sensor can be successfully applied for the quantitative determination of glucose in human serum. The results indicate that it is a simple, cheap, convenient, highly selective, sensitive, and easy handling colorimetric assay. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2011CB302100 ; 21121063 ; 91027018 ; 51172244 ; 11076027
项目资助者: 973 Program ; National Natural Science Foundation of China ; NSAF
WOS记录号: WOS:000320481900076
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63097
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

Recommended Citation:
Li, Ruimin,Zhen, Mingming,Guan, Mirong,et al. A novel glucose colorimetric sensor based on intrinsic peroxidase-like activity of C-60-carboxyfullerenes[J]. BIOSENSORS & BIOELECTRONICS,2013,47:502-507.
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