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Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors
Zhang, Chao; Li, Shasha; Ji, Liyan; Liu, Shan; Li, Zhongjun; Li, Shuchun; Meng, Xiangbao
关键词Anti-cancer Topo I Synthesis Inhibitor
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2015-10-15
DOI10.1016/j.bmcl.2015.06.042
25期:20页:4693-4696
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ANTINEOPLASTIC AGENTS ; PERSPECTIVES ; DERIVATIVES
英文摘要

Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000362102200062
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63099
专题北京大学药学院_化学生物学系
北京大学第二临床医学院_产科
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chao,Li, Shasha,Ji, Liyan,et al. Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(20):4693-4696.
APA Zhang, Chao.,Li, Shasha.,Ji, Liyan.,Liu, Shan.,Li, Zhongjun.,...&Meng, Xiangbao.(2015).Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(20),4693-4696.
MLA Zhang, Chao,et al."Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.20(2015):4693-4696.
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