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Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors
Zhang, Chao; Li, Shasha; Ji, Liyan; Liu, Shan; Li, Zhongjun; Li, Shuchun; Meng, Xiangbao
关键词Anti-cancer Topo I Synthesis Inhibitor
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2015-10-15
DOI10.1016/j.bmcl.2015.06.042
25期:20页:4693-4696
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
资助者National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC)
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ANTINEOPLASTIC AGENTS ; PERSPECTIVES ; DERIVATIVES
英文摘要

Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81273370
资助者National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC)
WOS记录号WOS:000362102200062
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63099
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chao,Li, Shasha,Ji, Liyan,et al. Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(20):4693-4696.
APA Zhang, Chao.,Li, Shasha.,Ji, Liyan.,Liu, Shan.,Li, Zhongjun.,...&Meng, Xiangbao.(2015).Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(20),4693-4696.
MLA Zhang, Chao,et al."Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.20(2015):4693-4696.
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