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学科主题: 药学
题名:
Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors
作者: Zhang, Chao; Li, Shasha; Ji, Liyan; Liu, Shan; Li, Zhongjun; Li, Shuchun; Meng, Xiangbao
关键词: Anti-cancer ; Topo I ; Synthesis ; Inhibitor
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2015-10-15
DOI: 10.1016/j.bmcl.2015.06.042
卷: 25, 期:20, 页:4693-4696
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: ANTINEOPLASTIC AGENTS ; PERSPECTIVES ; DERIVATIVES
英文摘要:

Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81273370
项目资助者: National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000362102200062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63099
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Chao,Li, Shasha,Ji, Liyan,et al. Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(20):4693-4696.
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