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学科主题: 临床医学
题名:
INTRAVITREAL VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION AND AXIAL LENGTH
作者: Hu, Qingjun1; Liu, Guohua1; Deng, Qing1; Wu, Qiuju1; Tao, Yong2,3; Jonas, Jost B.4
关键词: vascular endothelial growth factor ; VEGF ; myopia ; axial length
刊名: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
发表日期: 2015-03-01
卷: 35, 期:3, 页:435-439
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: AGE-RELATED MACULOPATHY ; MACULAR DEGENERATION ; DIABETIC-RETINOPATHY ; RISK-FACTORS ; AQUEOUS-HUMOR ; BEIJING EYE ; ASSOCIATIONS ; PREVALENCE ; SINGAPORE ; MYOPIA
英文摘要:

Background: To examine the intravitreal concentration of vascular endothelial growth factor (VEGF) in dependence of the axial length in eyes without intraocular neovascularization.

Methods: The concentrations of VEGF in vitreous samples and blood samples of patients undergoing pars plana vitrectomy for treatment of idiopathic macular holes or epiretinal membranes were examined using enzyme-linked immunosorbent assay. Axial length was determined by biometry.

Results: The study included 34 patients with macular holes (n = 21) or epiretinal membranes (n = 13) with a mean age of 62.4 +/- 10.5 years (range: 35-76 years) and a mean axial length of 24.1 +/- 1.8 mm (range: 21.0-29.1 mm). The intravitreal VEGF concentration (mean: 71.0 +/- 63.2 pg/mL) was significantly (P < 0.001) lower than the VEGF concentration in the blood (830 +/- 585 pg/mL). Both parameters were significantly associated with each other (P = 0.04; correlation coefficient r = 0.35). The intravitreal VEGF concentration was not significantly associated with gender (P = 0.25) or age (P = 0.48). A higher intravitreal VEGF concentration was significantly associated with a shorter axial length (P = 0.025; r = -0.39) or a higher hyperopic refractive error (P = 0.04; r = 0.35). Neither plasma concentration of VEGF nor the ratio of plasma VEGF concentrations to intravitreal VEGF concentration was significantly associated with axial length (P = 0.89 and P = 0.22, respectively) or with refractive error (P = 0.89 and P = 0.26, respectively).

Conclusion: Intravitreal VEGF concentration decreased with increasing axial length. It suggests a diluting effect in eyes with larger intraocular volume and/or a faster turnover rate of VEGF in axially myopic eyes with vitreous liquefaction.

语种: 英语
所属项目编号: 90561 ; NCET-12-0010
项目资助者: EFSD/CDS/Lilly grant ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000350293100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63101
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Civil Aviat Med Coll, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
3.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
4.Heidelberg Univ, Seegartenklin Heidelberg, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany

Recommended Citation:
Hu, Qingjun,Liu, Guohua,Deng, Qing,et al. INTRAVITREAL VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION AND AXIAL LENGTH[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,2015,35(3):435-439.
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