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学科主题: 临床医学
题名:
Ochroconis calidifluminalis, a Sibling of the Neurotropic Pathogen O. gallopava, Isolated from Hot Spring
作者: Yarita, Kyoko1; Sano, Ayako1; Samerpitak, Kittipan2; Kamei, Katsuhiko1; de Hoog, G. Sybren3,4,5; Nishimura, Kazuko1,6
关键词: Hot spring ; New species ; Ochroconis calidifluminalis ; Virulence
刊名: MYCOPATHOLOGIA
发表日期: 2010-07-01
DOI: 10.1007/s11046-010-9292-7
卷: 170, 期:1, 页:21-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: OF-THE-LITERATURE ; TRANSPLANT RECIPIENT ; AMPHOTERICIN-B ; INFECTION ; PHEOHYPHOMYCOSIS ; ITRACONAZOLE ; VORICONAZOLE ; PATIENT
英文摘要:

Two strains resembling the neurotropic fungus Ochroconis gallopava were isolated from hot spring river water (IFM 54738 and IFM 54739). The isolates showed optimal growth at 42A degrees C, while the maximum growth temperature was 49A degrees C, thus having temperature relationships similar to those of O. gallopava. Colonies were light olive green, with a color change to dark reddish brown after several passages, which was also observed in O. gallopava. Conidia were indistinguishable from those of O. gallopava. The antifungal susceptibility profile of the isolates was also similar to that of O. gallopava, except for a lower susceptibility to micafungin. The two isolates had 100% homologous rRNA genes including the internal transcribed spacer (ITS) region and the D1/D2 region of the large subunit. The gene fragments, as O. gallopava, could be amplified with species-specific rDNA primers, and loop-mediated isothermal amplification designed for O. gallopava yielded positive results in the two isolates. However, homologies with O. gallopava in ITS and D1/D2 regions were 79.2 and 95.9%, respectively, widely exceeding generally accepted species boundaries. These differences were corroborated in virulence tested in experimental infection. The two isolates did not kill a mouse even until 28 days. However, mortalities of four O. gallopava strains ranged from 40 to 100%. The new isolates mainly affected the kidneys; whereas O. gallopava had a strong preference for the brain. We therefore propose a new species, Ochroconis calidifluminalis, for the two isolates.

语种: 英语
项目资助者: Ministry of Health, Labour, and Welfare, Japan
WOS记录号: WOS:000278407900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63112
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
2.First Labs Co Ltd, Chiba, Japan
3.Chiba Univ, Med Mycol Res Ctr, Chiba, Japan
4.Khon Kaen Univ, Dept Microbiol, Fac Med, Khon Kaen, Thailand
5.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
6.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China

Recommended Citation:
Yarita, Kyoko,Sano, Ayako,Samerpitak, Kittipan,et al. Ochroconis calidifluminalis, a Sibling of the Neurotropic Pathogen O. gallopava, Isolated from Hot Spring[J]. MYCOPATHOLOGIA,2010,170(1):21-30.
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