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学科主题临床医学
DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer
Zhu, Jian1; Wang, Yuyan1; Duan, Jianchun1; Bai, Hua1; Wang, Zhijie1; Wei, Lai2; Zhao, Jun1; Zhuo, Minglei1; Wang, Shuhang1; Yang, Lu1; An, Tongtong1; Wu, Meina1; Wang, Jie1
关键词DNA methylation EGFR-TKI Wnt antagonists Non-small cell lung cancer
刊名JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
2012-09-25
DOI10.1186/1756-9966-31-80
31
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Sciences Foundation Distinguished Young Scholars ; National Natural Sciences Foundation General Program ; Beijing Health Systems Academic Leader ; National Natural Sciences Foundation Distinguished Young Scholars ; National Natural Sciences Foundation General Program ; Beijing Health Systems Academic Leader
研究领域[WOS]Oncology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; ACUTE MYELOID-LEUKEMIA ; PROMOTER HYPERMETHYLATION ; SIGNALING PATHWAY ; EPIGENETIC INACTIVATION ; GEFITINIB ; MUTATIONS ; GENE ; CHEMOTHERAPY ; EXPRESSION
英文摘要

Background: It is well known that genetic alternation of epidermal growth factor receptor (EGFR) plays critical roles in tumorgenesis of lung cancer and can predict outcome of non-small-cell lung cancer treatment, especially the EGFR tyrosine-kinase inhibitors (EGFR-TKIs) therapy. However, it is unclear whether epigenetic changes such as DNA methylation involve in the response to the EGFR-TKI therapy.

Methods: Tumor samples from 155 patients with stages IIIB to IV NSCLC who received EGFR-TKI therapy were analyzed for DNA methylation status of Wnt antagonist genes, including SFRP1, SFRP2, SFRP5, DKK3, WIF1, and APC, using methylation specific PCR (MSP) method. EGFR mutations detections were performed in the same tissues samples using Denaturing High Performance Liquid Chromatography (DHPLC).

Results: We found that Wnt antagonists tend to methylate simultaneously. Methylation of sFRP1 and sFRP5 are reversely correlated with EGFR mutation (P = 0.005, P = 0.011). However, no correlations of methylations of other Wnt antagonist genes with EGFR mutation were found. The patients with methylated SFRP5 have a significant shorter progression free survival than those with unmethylated SFRP5 in response to EGFR-TKI treatment (P = 0.002), which is independent of EGFR genotype.

Conclusions: Patients with unmethylated SFRP5 are more likely to benefit from EGFR-TKI therapy.

语种英语
所属项目编号81025012 ; 81172235 ; 2011-2-22
资助者National Natural Sciences Foundation Distinguished Young Scholars ; National Natural Sciences Foundation General Program ; Beijing Health Systems Academic Leader ; National Natural Sciences Foundation Distinguished Young Scholars ; National Natural Sciences Foundation General Program ; Beijing Health Systems Academic Leader
WOS记录号WOS:000312598700001
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63113
专题北京大学临床肿瘤学院_胸部肿瘤内科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Thorac Med Oncol, Beijing 100036, Peoples R China
2.NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA
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GB/T 7714
Zhu, Jian,Wang, Yuyan,Duan, Jianchun,et al. DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2012,31.
APA Zhu, Jian.,Wang, Yuyan.,Duan, Jianchun.,Bai, Hua.,Wang, Zhijie.,...&Wang, Jie.(2012).DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,31.
MLA Zhu, Jian,et al."DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 31(2012).
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