北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 计划生育与生殖医学科  > 期刊论文
学科主题: 临床医学
题名:
Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment
作者: Tian, Li; Shen, Huan; Lu, Qun; Norman, Robert J.; Wang, Jim
刊名: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
发表日期: 2007-04-01
DOI: 10.1210/jc.2006-1123
卷: 92, 期:4, 页:1430-1433
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: POLYCYSTIC-OVARY-SYNDROME ; HOMEOSTASIS MODEL ASSESSMENT ; WOMEN ; METFORMIN ; OBESITY ; PREVALENCE
英文摘要:

Objective: This study aims to examine the impact of insulin resistance (IR) on the risk of spontaneous abortion in patients who received infertility treatment.

Patients and Methods: This is a cohort study of 107 patients who achieved their first pregnancy after infertility treatment in a tertiary medical center. A homeostasis model assessment of IR (HOMA-IR) was carried out. Patient demographic characteristics and pregnancy outcome were also recorded. Statistical comparison was made between patients with and without IR. Logistical regression analysis was used to assess the effect of IR and several other factors simultaneously on the risk of spontaneous abortion.

Results: The incidence of spontaneous abortion was 17.8%. The association of IR with the risk of spontaneous abortion was significant after adjusting for other risk factors. The effect of overweight/obesity and polycystic ovarian syndrome was not statistically significant in the multivariate model.

Discussion and Conclusion: This study suggested that IR was an independent risk factor for spontaneous abortion. Because of the high prevalence of IR in obese or polycystic ovarian syndrome patients, the risk of spontaneous abortion in these patients can be raised. Patients with IR should be advised to improve their insulin sensitivity through lifestyle change or medical intervention before infertility treatment to reduce their risk of spontaneous abortion.

语种: 英语
WOS记录号: WOS:000245466600040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63114
Appears in Collections:北京大学第二临床医学院_计划生育与生殖医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Univ, Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China
2.Univ Adelaide, Queen Elizabeth Hosp, Res Ctr Reprod Hlth, Woodville, SA 5011, Australia
3.Univ Adelaide, Queen Elizabeth Hosp, Dept Obstet & Gynaecol, Woodville, SA 5011, Australia

Recommended Citation:
Tian, Li,Shen, Huan,Lu, Qun,et al. Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2007,92(4):1430-1433.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tian, Li]'s Articles
[Shen, Huan]'s Articles
[Lu, Qun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tian, Li]‘s Articles
[Shen, Huan]‘s Articles
[Lu, Qun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace