IR@PKUHSC  > 北京大学第二临床医学院  > 计划生育与生殖医学科
学科主题临床医学
Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment
Tian, Li; Shen, Huan; Lu, Qun; Norman, Robert J.; Wang, Jim
刊名JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
2007-04-01
DOI10.1210/jc.2006-1123
92期:4页:1430-1433
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]POLYCYSTIC-OVARY-SYNDROME ; HOMEOSTASIS MODEL ASSESSMENT ; WOMEN ; METFORMIN ; OBESITY ; PREVALENCE
英文摘要

Objective: This study aims to examine the impact of insulin resistance (IR) on the risk of spontaneous abortion in patients who received infertility treatment.

Patients and Methods: This is a cohort study of 107 patients who achieved their first pregnancy after infertility treatment in a tertiary medical center. A homeostasis model assessment of IR (HOMA-IR) was carried out. Patient demographic characteristics and pregnancy outcome were also recorded. Statistical comparison was made between patients with and without IR. Logistical regression analysis was used to assess the effect of IR and several other factors simultaneously on the risk of spontaneous abortion.

Results: The incidence of spontaneous abortion was 17.8%. The association of IR with the risk of spontaneous abortion was significant after adjusting for other risk factors. The effect of overweight/obesity and polycystic ovarian syndrome was not statistically significant in the multivariate model.

Discussion and Conclusion: This study suggested that IR was an independent risk factor for spontaneous abortion. Because of the high prevalence of IR in obese or polycystic ovarian syndrome patients, the risk of spontaneous abortion in these patients can be raised. Patients with IR should be advised to improve their insulin sensitivity through lifestyle change or medical intervention before infertility treatment to reduce their risk of spontaneous abortion.

语种英语
WOS记录号WOS:000245466600040
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63114
Collection北京大学第二临床医学院_计划生育与生殖医学科
作者单位1.Beijing Univ, Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China
2.Univ Adelaide, Queen Elizabeth Hosp, Res Ctr Reprod Hlth, Woodville, SA 5011, Australia
3.Univ Adelaide, Queen Elizabeth Hosp, Dept Obstet & Gynaecol, Woodville, SA 5011, Australia
Recommended Citation
GB/T 7714
Tian, Li,Shen, Huan,Lu, Qun,et al. Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2007,92(4):1430-1433.
APA Tian, Li,Shen, Huan,Lu, Qun,Norman, Robert J.,&Wang, Jim.(2007).Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,92(4),1430-1433.
MLA Tian, Li,et al."Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 92.4(2007):1430-1433.
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