|Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy|
|Pu, YL; Li, QF; Zeng, CM; Gao, J; Qi, J; Luo, DX; Mahankali, S; Fox, PT; Gao, JH|
|刊名||AMERICAN JOURNAL OF NEURORADIOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging|
|研究领域[WOS]||Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging|
|关键词[WOS]||MAGNETIC-RESONANCE SPECTROSCOPY ; EXCITATORY AMINO-ACIDS ; NMR-SPECTROSCOPY ; IN-VIVO ; PROTON SPECTROSCOPY ; STIMULATED ECHOES ; H-1 SPECTROSCOPY ; H-1-NMR SPECTRA ; GLUTAMATE ; NEWBORN|
BACKGROUND AND PURPOSE: Proton MR spectroscopy (MRS) detectability of brain glutamate/glutamine (Glx) is increased in hypoxic-ischemic insults and is implicated in the neuronal injury and death that follows. Our aim was to correlate the proton MRS detectability of alpha-CH protons of Glx (alpha-Glx) with the Sarnat stage of neonatal hypoxic-ischemic encephalopathy (HIE).
METHODS: Initial and follow-up proton MRS studies at 1.9 T were performed in 28 neonates aged 1 to 7 days (seven healthy control subjects and 21 with HIE: 10 mild, nine moderate, and two severe) and in 12 neonates aged 13 to 17 days (12 with HIE: eight mild, three moderate, and one severe), respectively. Both point-resolved spectroscopy (PRESS) and stimulated-echo acquisition mode (STEAM) sequences were used, The spectral volume of interest was in the basal ganglia, thalami, and adjoining regions. The detectability of alpha-Glx was assessed by two different parameters: the detection rate of the a-Glx peak and the peak-area ratio of alpha-Glx to creatine and phosphocreatine.
RESULTS: On both the initial and follow-up PRESS studies, all the neonates with moderate and severe HIE showed an a-Glx peak, compared with one healthy control subject in the initial study and one neonate with mild HIE in both the studies. They also demonstrated a significantly higher peak-area ratio of alpha-Glx/(creatine and phosphocreatine) on both the initial and followup studies. The peak-area ratios in neonates with HIE positively correlated with the Sarnat stage of HIE on both the initial and follow-up studies. Neonates with moderate and severe HIE also showed a consistently higher alpha-Glx peak on both the initial and follow-up studies with the STEAM sequence.
CONCLUSION: Proton MRS detectability of alpha-Glx is increased in moderate and severe HIE and correlates with the Sarnat stage of HIE.
|作者单位||1.Univ Texas, Hlth Sci Ctr, Res Imaging Ctr, San Antonio, TX 78284 USA|
2.Beijing Med Univ, Peoples Hosp, Beijing 100083, Peoples R China
|Pu, YL,Li, QF,Zeng, CM,et al. Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2000,21(1):203-212.|
|APA||Pu, YL.,Li, QF.,Zeng, CM.,Gao, J.,Qi, J.,...&Gao, JH.(2000).Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy.AMERICAN JOURNAL OF NEURORADIOLOGY,21(1),203-212.|
|MLA||Pu, YL,et al."Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy".AMERICAN JOURNAL OF NEURORADIOLOGY 21.1(2000):203-212.|