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学科主题: 临床医学
题名:
Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy
作者: Pu, YL; Li, QF; Zeng, CM; Gao, J; Qi, J; Luo, DX; Mahankali, S; Fox, PT; Gao, JH
刊名: AMERICAN JOURNAL OF NEURORADIOLOGY
发表日期: 2000
卷: 21, 期:1, 页:203-212
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MAGNETIC-RESONANCE SPECTROSCOPY ; EXCITATORY AMINO-ACIDS ; NMR-SPECTROSCOPY ; IN-VIVO ; PROTON SPECTROSCOPY ; STIMULATED ECHOES ; H-1 SPECTROSCOPY ; H-1-NMR SPECTRA ; GLUTAMATE ; NEWBORN
英文摘要:

BACKGROUND AND PURPOSE: Proton MR spectroscopy (MRS) detectability of brain glutamate/glutamine (Glx) is increased in hypoxic-ischemic insults and is implicated in the neuronal injury and death that follows. Our aim was to correlate the proton MRS detectability of alpha-CH protons of Glx (alpha-Glx) with the Sarnat stage of neonatal hypoxic-ischemic encephalopathy (HIE).

METHODS: Initial and follow-up proton MRS studies at 1.9 T were performed in 28 neonates aged 1 to 7 days (seven healthy control subjects and 21 with HIE: 10 mild, nine moderate, and two severe) and in 12 neonates aged 13 to 17 days (12 with HIE: eight mild, three moderate, and one severe), respectively. Both point-resolved spectroscopy (PRESS) and stimulated-echo acquisition mode (STEAM) sequences were used, The spectral volume of interest was in the basal ganglia, thalami, and adjoining regions. The detectability of alpha-Glx was assessed by two different parameters: the detection rate of the a-Glx peak and the peak-area ratio of alpha-Glx to creatine and phosphocreatine.

RESULTS: On both the initial and follow-up PRESS studies, all the neonates with moderate and severe HIE showed an a-Glx peak, compared with one healthy control subject in the initial study and one neonate with mild HIE in both the studies. They also demonstrated a significantly higher peak-area ratio of alpha-Glx/(creatine and phosphocreatine) on both the initial and followup studies. The peak-area ratios in neonates with HIE positively correlated with the Sarnat stage of HIE on both the initial and follow-up studies. Neonates with moderate and severe HIE also showed a consistently higher alpha-Glx peak on both the initial and follow-up studies with the STEAM sequence.

CONCLUSION: Proton MRS detectability of alpha-Glx is increased in moderate and severe HIE and correlates with the Sarnat stage of HIE.

语种: 英语
WOS记录号: WOS:000085055900041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63115
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Texas, Hlth Sci Ctr, Res Imaging Ctr, San Antonio, TX 78284 USA
2.Beijing Med Univ, Peoples Hosp, Beijing 100083, Peoples R China

Recommended Citation:
Pu, YL,Li, QF,Zeng, CM,et al. Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2000,21(1):203-212.
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