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学科主题: 公共卫生
题名:
Soyfood intake in the prevention of breast cancer risk in women: A meta-analysis of observational epidemiological studies
作者: Qin, Li-Qiang; Xu, Jia-Ying; Wang, Pei-Yu; Hoshi, Kazuhiko
关键词: breast cancer ; soyfood ; isoflavone ; meta-analysis
刊名: JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
发表日期: 2006-12-01
卷: 52, 期:6, 页:428-436
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: ASIAN-AMERICANS ; SOY INTAKE ; DIETARY GENISTEIN ; MENOPAUSAL STATUS ; PROSTATE-CANCER ; CHINESE WOMEN ; SHANGHAI ; POPULATION ; FOODS ; PREMENOPAUSAL
英文摘要:

Many studies have suggested that the intake of soy products may protect against the occurrence of breast cancer because of the considerable amount of isoflavones they contain. To review the results of the observational studies, we performed this metaanalysis of the relevant literature. We searched Medline for reports that examined the association between soyfood consumption (or isoflavone intake) and breast cancer risk from January 1966 to April 2006. The random-effects model was used to estimate the pooled relative risk (RR). Twenty-one independent studies (14 case-control studies and 7 cohort studies) were included in the final analysis. The pooled RR of breast cancer for soyfood intake was 0.75 with a 95% CI of 0.59-0.95. As the main types of soyfood in Japan and China, tofu and miso showed clear protective effects. Isoflavone intake resulted in a 20% decrease in risk (RR=0.81, 95% CI 0.67-0.99). The pooled RR varied little according to study stratification. When the studies published in Japanese and Chinese were added, the inverse associations between soyfood, tofu and breast cancer risk became slightly stronger. The weak association of miso was possibly due to the high concentration of salt in miso soup. In the present analysis, we did not find strong evidence for publication bias in the combination of the studies. This meta-analysis supported the hypotheses that soyfood intake may be associated with a decreased risk of breast cancer due to the isoflavones. Further epidemiological studies need to be conducted with more comprehensive information about the soyfood, and more accurate assessment of the isoflavones.

语种: 英语
WOS记录号: WOS:000243208000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63117
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Univ Yamanashi, Sch Med, Dept Obstet & Gynecol, Yamanashi 4093898, Japan
2.Soochow Univ, Sch Radiol & Publ Hlth, Suzhou 215123, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100083, Peoples R China

Recommended Citation:
Qin, Li-Qiang,Xu, Jia-Ying,Wang, Pei-Yu,et al. Soyfood intake in the prevention of breast cancer risk in women: A meta-analysis of observational epidemiological studies[J]. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY,2006,52(6):428-436.
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