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学科主题: 药学
题名:
Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in Macrophages
作者: Zheng, Jiao1,3; Tang, Li1; Xian, Xun-De2; Zhou, Si-Xiang1; Shi, Hai-Ming1; Jiang, Yong1; Gu, Yue-Qing3; Liu, George2; Tu, Peng-Fei1,3
关键词: Ilex kudingcha ; Aquifoliaceae ; anti-atherosclerosis ; structure-activity relationship ; foam cells ; triterpenoid saponins
刊名: PLANTA MEDICA
发表日期: 2009-10-01
DOI: 10.1055/s-0029-1185722
卷: 75, 期:13, 页:1410-1414
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: KUDINCHA ; EFFLUX ; CELLS
英文摘要:

We have investigated the inhibitory effect of triterpenoid saponins from the leaves of flex kudingcha C.J. Tseng on aggregated low-density lipoprotein (LDL)-induced lipid deposition in macrophages. A cell-based screening model was initially applied on aggregated LDL (aggLDL)-induced lipid deposition on macrophages to test the inhibitory effects of the 12 triterpenoid saponins from this plant. Eight of these compounds inhibited the formation of foam cells and reduced intracellular total cholesterol and triglyceride contents. Structure-activity relationship analysis showed the essential role of the delta-lactone ring for the biological activity. The promoter action of the OH group at the C-12 position, the number of monosaccharides in the sugar chain and the rhamnose at the terminal of the sugar chain is also discussed.

语种: 英语
所属项目编号: 30672608 ; 985-2-063-112
项目资助者: National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University
WOS记录号: WOS:000271577000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63123
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Inst Cardiovasc Sci, Key Lab Mol Cardiol, Minist Educ, Beijing 100191, Peoples R China
3.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Peoples R China

Recommended Citation:
Zheng, Jiao,Tang, Li,Xian, Xun-De,et al. Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in Macrophages[J]. PLANTA MEDICA,2009,75(13):1410-1414.
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