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Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in Macrophages
Zheng, Jiao1,3; Tang, Li1; Xian, Xun-De2; Zhou, Si-Xiang1; Shi, Hai-Ming1; Jiang, Yong1; Gu, Yue-Qing3; Liu, George2; Tu, Peng-Fei1,3
关键词Ilex kudingcha Aquifoliaceae anti-atherosclerosis structure-activity relationship foam cells triterpenoid saponins
刊名PLANTA MEDICA
2009-10-01
DOI10.1055/s-0029-1185722
75期:13页:1410-1414
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University ; National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]KUDINCHA ; EFFLUX ; CELLS
英文摘要

We have investigated the inhibitory effect of triterpenoid saponins from the leaves of flex kudingcha C.J. Tseng on aggregated low-density lipoprotein (LDL)-induced lipid deposition in macrophages. A cell-based screening model was initially applied on aggregated LDL (aggLDL)-induced lipid deposition on macrophages to test the inhibitory effects of the 12 triterpenoid saponins from this plant. Eight of these compounds inhibited the formation of foam cells and reduced intracellular total cholesterol and triglyceride contents. Structure-activity relationship analysis showed the essential role of the delta-lactone ring for the biological activity. The promoter action of the OH group at the C-12 position, the number of monosaccharides in the sugar chain and the rhamnose at the terminal of the sugar chain is also discussed.

语种英语
所属项目编号30672608 ; 985-2-063-112
资助者National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University ; National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University
WOS记录号WOS:000271577000007
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63123
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Inst Cardiovasc Sci, Key Lab Mol Cardiol, Minist Educ, Beijing 100191, Peoples R China
3.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Peoples R China
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GB/T 7714
Zheng, Jiao,Tang, Li,Xian, Xun-De,et al. Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in Macrophages[J]. PLANTA MEDICA,2009,75(13):1410-1414.
APA Zheng, Jiao.,Tang, Li.,Xian, Xun-De.,Zhou, Si-Xiang.,Shi, Hai-Ming.,...&Tu, Peng-Fei.(2009).Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in Macrophages.PLANTA MEDICA,75(13),1410-1414.
MLA Zheng, Jiao,et al."Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in Macrophages".PLANTA MEDICA 75.13(2009):1410-1414.
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