IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Pulmonary function testing in patients with pulmonary arterial hypertension
Jing, Zhi-Cheng1,2,3; Xu, Xi-Qi1,4; Badesch, David B.5; Jiang, Xin1; Wu, Yan2,3; Liu, Jin-Ming1; Wang, Yong6; Pan, Lei6; Li, Hui-Ping1; Pu, Jie-Lin2,3; Zhang, Zhuo-Li7; Yang, Yue-Jin2,3
关键词Airway obstruction Pulmonary arterial hypertension Pulmonary function test Pulmonary diffusion capacity
刊名RESPIRATORY MEDICINE
2009-08-01
DOI10.1016/j.rmed.2009.03.009
103期:8页:1136-1142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Respiratory System
资助者China National 973 Project ; China National 973 Project
研究领域[WOS]Cardiovascular System & Cardiology ; Respiratory System
关键词[WOS]OBSTRUCTION ; GUIDELINES ; EXPRESSION ; DIAGNOSIS ; LUNGS
英文摘要

Background: Although previous studies have shown that peripheral airway obstruction can occur in idiopathic PAH (IPAH), pulmonary function tests have not been well-studied in patients with PAH associated with congenital heart disease (CHD-PAH) and connective tissue disease (CTD-PAH).

Methods: A multicenter prospective study was performed in PAH patients in China. Pulmonary function tests were evaluated in 190 PAH patients.

Results: Total lung capacity (TLC), residual volume (RV) and total airway resistance (Rtot) were similar in PAH patients and controls. However, measures of airflow, including vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 s(FEV(1)), FEV(1)/FVC and MEF(50) were decreased in PAH group. Single-breath diffusion capacity for carbon monoxide (DL(CO)) was also decreased in PAH patients. Expiratory flow-volume curves showed reduction and a curvilinear appearance in patients with PAH. Similar changes were observed among the various subgroups of IPAH, CHD-PAH, and CTD-PAH patients. More CTD-PAH patients had abnormal DL(CO).

Conclusions: Airway obstruction is common in IPAH, CHD-PAH and CTD-PAH patients. CTD-PAH patients have lower DL(CO). Hemodynamics, serum markers and exercise capacity parameters did not correlate well with pulmonary function indices. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号2007CB512008
资助者China National 973 Project ; China National 973 Project
WOS记录号WOS:000268148100006
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63131
Collection北京大学第一临床医学院
作者单位1.Tongji Univ, Shanghai Pulm Hosp, Dept Pulm Circulat, Shanghai 200433, Peoples R China
2.Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100037, Peoples R China
3.Peking Union Med Coll, Beijing 100021, Peoples R China
4.Aviat Ind Cent Hosp, Beijing, Peoples R China
5.Univ Colorado, Hlth Sci Ctr, Boulder, CO 80309 USA
6.Peking Univ, Beijing Shijitan Hosp, Beijing 100871, Peoples R China
7.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Jing, Zhi-Cheng,Xu, Xi-Qi,Badesch, David B.,et al. Pulmonary function testing in patients with pulmonary arterial hypertension[J]. RESPIRATORY MEDICINE,2009,103(8):1136-1142.
APA Jing, Zhi-Cheng.,Xu, Xi-Qi.,Badesch, David B..,Jiang, Xin.,Wu, Yan.,...&Yang, Yue-Jin.(2009).Pulmonary function testing in patients with pulmonary arterial hypertension.RESPIRATORY MEDICINE,103(8),1136-1142.
MLA Jing, Zhi-Cheng,et al."Pulmonary function testing in patients with pulmonary arterial hypertension".RESPIRATORY MEDICINE 103.8(2009):1136-1142.
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