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The effects of over-expression and suppression of Cdc25A on the S-phase checkpoint induced by benzo(a)pyrene
Yao, Biyun; Fu, Juanling; Hu, Entan; Qi, Yanmin; Zhou, Zongcan
关键词benzo(a)pyrene (BaP) Cdc25A cell cycle S-phase checkpoint
刊名TOXICOLOGY
2008-04-18
DOI10.1016/j.tox.2008.01.016
246期:2-3页:180-187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]CELL-CYCLE CHECKPOINTS ; DNA-DAMAGE CHECKPOINT ; PATHWAY ; CANCER ; PHOSPHORYLATION ; INACTIVATION ; REPLICATION ; INHIBITORS ; INITIATION ; MECHANISM
英文摘要

Our previous results have indicated that Cdc25A is involved in benzo(a)pyrene (BaP)-induced S-phase checkpoint in 16HBE cells and A549 cells. In this paper, we reported the changes of the downstream molecular pathway of Cdc25A and the effects of over-expression and suppression of Cdc25A on BaP-induced S-phase checkpoint. In the S-phase checkpoint induced by BaP the reduction of Cdc25A contributes to cyclin A inhibition. Over-expression of Cdc25A abrogated BaP-induced S-phase arrest in 16HBE cells and concomitantly the expression levels of Cdk2 and cyclin A were not obviously changed by BaP when compared with the control. Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000255320800011
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63133
专题北京大学公共卫生学院_毒理学系
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100083, Peoples R China
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Yao, Biyun,Fu, Juanling,Hu, Entan,et al. The effects of over-expression and suppression of Cdc25A on the S-phase checkpoint induced by benzo(a)pyrene[J]. TOXICOLOGY,2008,246(2-3):180-187.
APA Yao, Biyun,Fu, Juanling,Hu, Entan,Qi, Yanmin,&Zhou, Zongcan.(2008).The effects of over-expression and suppression of Cdc25A on the S-phase checkpoint induced by benzo(a)pyrene.TOXICOLOGY,246(2-3),180-187.
MLA Yao, Biyun,et al."The effects of over-expression and suppression of Cdc25A on the S-phase checkpoint induced by benzo(a)pyrene".TOXICOLOGY 246.2-3(2008):180-187.
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