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学科主题: 临床医学
题名:
An open, comparative, multicentre clinical study of combined oral therapy with sildenafil and doxazosin GITS for treating Chinese patients with erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia
作者: Jin, Zhe1; Zhang, Zhi-Chao1; Liu, Ji-Hong2; Lu, Jun3; Tang, Yu-Xin4; Sun, Xiang-Zhou5; Song, Wei-Dong1; Gao, Bing1; Guo, Ying-Lu1; Xin, Zhong-Cheng1
关键词: doxazosin GITS ; erectile dysfunction ; IPSS ; lower urinary tract symptoms ; quality of life ; sildenafil
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2011-07-01
DOI: 10.1038/aja.2010.177
卷: 13, 期:4, 页:630-635
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: SEXUAL DYSFUNCTION ; MEN ; TADALAFIL ; REGISTRY ; TISSUE
英文摘要:

This study sought to investigate the clinical efficacy and safety of combined oral therapy with sildenafil and doxazosin GITS compared to sildenafil monotherapy in treating Chinese patients with erectile dysfunction (ED) and lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH/LUTS). The trial was conducted in hospitals in Beijing, Shanghai, Changsha, Wuhan and Guangzhou, five major cities in China. A total of 250 patients diagnosed with ED and BPH/LUTS aged 50-75 years, and who had International Index of Erection Function-5 (IIEF-5) scores <= 21 and International Prostate Symptom Score (IPSS) >= 10 points, were enrolled and randomly divided into Group A (168 cases; doxazosin GITS 4 mg once daily plus sildenafil 25-100 mg on demand) and Group B (82 cases; sildenafil 25-100 mg on demand). Efficacies were evaluated by IIEF-5 and IPSS scores and a quality of life (QoL) questionnaire, and adverse effects were evaluated during the treatment period. There were no statistically significant differences in mean age, and IIEF-5, IPSS and QoL scores pre-treatment between the two groups. After treatment, IIEF-5, IPSS and QoL scores were significantly improved in Group A, while only IIEF-5 scores were significantly improved in Group B compared with pre-treatment. There were no significant differences in side effects between the two groups. The results indicated that combined therapy with sildenafil and doxazosin GITS for the treatment of ED and BPH/LUTS is safe and effective compared to sildenafil monotherapy. Asian Journal of Andrology (2011) 13, 630-635; doi: 10.1038/aja.2010.177; published online 23 May 2011

语种: 英语
项目资助者: Pfizer Inc. (Cardura XL) ; Pfizer Inc., Dalian, China ; Pfizer Inc.
WOS记录号: WOS:000292321700030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63135
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Urol, Tongji Hosp, Wuhan 430030, Peoples R China
3.Shanghai Jiao Tong Univ, Affiliated Hosp 1, Dept Urol, Shanghai 200080, Peoples R China
4.Cent S Univ, Xiangya Hosp 3, Dept Urol, Changsha 410013, Hunan, Peoples R China
5.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou 510080, Guangdong, Peoples R China

Recommended Citation:
Jin, Zhe,Zhang, Zhi-Chao,Liu, Ji-Hong,et al. An open, comparative, multicentre clinical study of combined oral therapy with sildenafil and doxazosin GITS for treating Chinese patients with erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia[J]. ASIAN JOURNAL OF ANDROLOGY,2011,13(4):630-635.
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