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学科主题: 公共卫生
题名:
Antidepressant prophylaxis for poststroke depression: a meta-analysis
作者: Chen, Yan; Patel, Nick C.; Guo, Jeff J.; Zhan, Siyan
关键词: antidepressants ; meta-analysis ; poststroke depression ; prophylaxis
刊名: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
发表日期: 2007-05-01
卷: 22, 期:3, 页:159-166
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: SEROTONIN-REUPTAKE INHIBITORS ; DOUBLE-BLIND TRIAL ; STROKE PATIENTS ; FUNCTIONAL RECOVERY ; MOOD DISORDERS ; FOLLOW-UP ; RISK ; PREVENTION ; FLUOXETINE ; THERAPY
英文摘要:

Given the high incidence of poststroke depression, its serious sequelae, and inherent problems with diagnosis, prophylactic use of antidepressants may be a viable management strategy in patients experiencing stroke. The purpose of this study was to assess the prophylactic effects of antidepressants in nondepressed patients with stroke. A meta-analysis of randomized placebo-controlled trials evaluating the prophylactic effects of antidepressants in nondepressed patients with stroke was conducted. Literature searches in MEDLINE, PubMed, CINAHL, PsycINFO, EMBASE, Cochrane library, and CNKI from 1950 to August 2006 were used to identify the relevant studies. Outcome measures included the occurrence rate of newly developed poststroke depression cases and severity of depressive symptoms as indicated by mean depression rating scale scores. The effect size was presented as rate difference or weighted mean difference. From 10 randomized clinical trials, a total of 703 nondepressed patients after stroke were identified, The pooled occurrence rate of newly developed poststroke depression cases in the intervention and control groups were 12.54 (41/327) and 29.17% (91/312), respectively (pooled rate difference= -0.17, 95% confidence interval: -0.26 to -0.08). Prophylactic effects of antidepressants were not related to duration of use {coefficient of Pearson′s correlation [gamma] = 0.57, P= 0.111. In conclusion, antidepressant prophylaxis is associated with a significant reduction in the occurrence rate of newly developed poststroke depression, suggesting antidepressants may be considered along with other vascular preventive strategies in the management of stroke patients.

语种: 英语
WOS记录号: WOS:000245935400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63136
Appears in Collections:北京大学公共卫生学院_流行病与卫生统计学系_期刊论文

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作者单位: 1.Univ Cincinnati, Sch Pharm, Div Pharm Practice & Adm Sci, Cincinnati, OH 45267 USA
2.Univ Cincinnati, Med Ctr, Coll Med, Dept Psychiat, Cincinnati, OH 45267 USA
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol, Beijing, Peoples R China

Recommended Citation:
Chen, Yan,Patel, Nick C.,Guo, Jeff J.,et al. Antidepressant prophylaxis for poststroke depression: a meta-analysis[J]. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY,2007,22(3):159-166.
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