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学科主题: 临床医学
题名:
Emerging role of interleukin-33 in autoimmune diseases
作者: Pei, Cheng1,2; Barbour, Mark1; Fairlie-Clarke, Karen J.1; Allan, Debbie1; Mu, Rong3; Jiang, Hui-Rong1
关键词: autoimmune diseases ; inflammation ; interleukin-33 ; ST2
刊名: IMMUNOLOGY
发表日期: 2014
DOI: 10.1111/imm.12174
卷: 141, 期:1, 页:9-17
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: INFLAMMATORY-BOWEL-DISEASE ; MEDIATED AIRWAY INFLAMMATION ; INNATE LYMPHOID-CELLS ; ULCERATIVE-COLITIS ; MAST-CELLS ; INDUCED ARTHRITIS ; SOLUBLE ST2 ; RHEUMATOID-ARTHRITIS ; ATOPIC-DERMATITIS ; IL-33 EXPRESSION
英文摘要:

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin-33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL-33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development.

语种: 英语
项目资助者: Medical Research Scotland
WOS记录号: WOS:000327947000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63137
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland
2.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Ophthalmol, Xian 710049, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Rheumatol & Immunol, Beijing 100871, Peoples R China

Recommended Citation:
Pei, Cheng,Barbour, Mark,Fairlie-Clarke, Karen J.,et al. Emerging role of interleukin-33 in autoimmune diseases[J]. IMMUNOLOGY,2014,141(1):9-17.
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