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学科主题: 临床医学
题名:
Differences in Aqueous Concentrations of Cytokines in Macular Edema Secondary to Branch and Central Retinal Vein Occlusion
作者: Feng, Jing; Zhao, Tong; Zhang, Yan; Ma, Yan; Jiang, Yanrong1
刊名: PLOS ONE
发表日期: 2013-07-05
DOI: 10.1371/journal.pone.0068149
卷: 8, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: FIBROBLAST-GROWTH-FACTOR ; PROLIFERATIVE DIABETIC-RETINOPATHY ; INTRAVITREAL TRIAMCINOLONE ; BEVACIZUMAB AVASTIN ; INTERLEUKIN-6 ; EXPRESSION ; NEOVASCULARIZATION ; RANIBIZUMAB ; POPULATION ; STATES
英文摘要:

Purpose: This study investigates the differential aqueous concentrations of interleukin 6, 8, 1 beta (IL-6, IL-8, IL-1 beta, respectively), serum amyloid A (SAA), transforming growth factor (TGF)-beta, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in eyes with macular edema as a result of a branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO)

Principal Findings: Significantly higher concentrations of IL-6, IL-8, IL-1 beta, TGF-beta, bFGF, SAA, and VEGF were found in the aqueous humor of CRVO and BRVO patients than in the aqueous humor of control patients. A significant correlation was observed between the concentration of bFGF and the inner central macular thickness (CMT) of BRVO patients (r = 0.688; P = 0.02). A significant correlation was observed between the concentration of SAA and both the full and outer CMT of the ischemic group (r = 0.545 and 0.683, respectively; P = 0.04 and 0.01, respectively). In the non-ischemic group, the level of IL-6 was significantly associated with inner CMT (r = 0.560; P = 0.03). The full and outer CMT was significantly reduced in CRVO patients when compared with BRVO patients (P = 0.02 and 0.02, respectively) after injection of intravitreal bevacizumab (IVB) at 4 weeks.

Significance: Serum amyloid A as a major protein involved in the acute and chronic stages of inflammation, and IL-6 and bFGF were significantly associated with the extent of macular edema in patients with RVO. Besides VEGF, other inflammatory cytokines and angiogenesic factors may be associated with RVO. This finding may have implications for the medical treatment of RVO.

语种: 英语
所属项目编号: RDC2012-21 ; 20110001110042
项目资助者: People&prime ; s Hospital of Peking University ; Ph.D. Programs Foundation of Ministry of Education of China ; EFSD/CDS/Lilly grant
WOS记录号: WOS:000321425300045
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63146
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China

Recommended Citation:
Feng, Jing,Zhao, Tong,Zhang, Yan,et al. Differences in Aqueous Concentrations of Cytokines in Macular Edema Secondary to Branch and Central Retinal Vein Occlusion[J]. PLOS ONE,2013,8(7).
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