IR@PKUHSC  > 北京大学第二临床医学院  > 眼科
学科主题临床医学
Differences in Aqueous Concentrations of Cytokines in Macular Edema Secondary to Branch and Central Retinal Vein Occlusion
Feng, Jing; Zhao, Tong; Zhang, Yan; Ma, Yan; Jiang, Yanrong1
刊名PLOS ONE
2013-07-05
DOI10.1371/journal.pone.0068149
8期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者People&prime ; s Hospital of Peking University ; Ph.D. Programs Foundation of Ministry of Education of China ; EFSD/CDS/Lilly grant ; People&prime ; s Hospital of Peking University ; Ph.D. Programs Foundation of Ministry of Education of China ; EFSD/CDS/Lilly grant
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]FIBROBLAST-GROWTH-FACTOR ; PROLIFERATIVE DIABETIC-RETINOPATHY ; INTRAVITREAL TRIAMCINOLONE ; BEVACIZUMAB AVASTIN ; INTERLEUKIN-6 ; EXPRESSION ; NEOVASCULARIZATION ; RANIBIZUMAB ; POPULATION ; STATES
英文摘要

Purpose: This study investigates the differential aqueous concentrations of interleukin 6, 8, 1 beta (IL-6, IL-8, IL-1 beta, respectively), serum amyloid A (SAA), transforming growth factor (TGF)-beta, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in eyes with macular edema as a result of a branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO)

Principal Findings: Significantly higher concentrations of IL-6, IL-8, IL-1 beta, TGF-beta, bFGF, SAA, and VEGF were found in the aqueous humor of CRVO and BRVO patients than in the aqueous humor of control patients. A significant correlation was observed between the concentration of bFGF and the inner central macular thickness (CMT) of BRVO patients (r = 0.688; P = 0.02). A significant correlation was observed between the concentration of SAA and both the full and outer CMT of the ischemic group (r = 0.545 and 0.683, respectively; P = 0.04 and 0.01, respectively). In the non-ischemic group, the level of IL-6 was significantly associated with inner CMT (r = 0.560; P = 0.03). The full and outer CMT was significantly reduced in CRVO patients when compared with BRVO patients (P = 0.02 and 0.02, respectively) after injection of intravitreal bevacizumab (IVB) at 4 weeks.

Significance: Serum amyloid A as a major protein involved in the acute and chronic stages of inflammation, and IL-6 and bFGF were significantly associated with the extent of macular edema in patients with RVO. Besides VEGF, other inflammatory cytokines and angiogenesic factors may be associated with RVO. This finding may have implications for the medical treatment of RVO.

语种英语
所属项目编号RDC2012-21 ; 20110001110042
资助者People&prime ; s Hospital of Peking University ; Ph.D. Programs Foundation of Ministry of Education of China ; EFSD/CDS/Lilly grant ; People&prime ; s Hospital of Peking University ; Ph.D. Programs Foundation of Ministry of Education of China ; EFSD/CDS/Lilly grant
WOS记录号WOS:000321425300045
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63146
专题北京大学第二临床医学院_眼科
作者单位1.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Feng, Jing,Zhao, Tong,Zhang, Yan,et al. Differences in Aqueous Concentrations of Cytokines in Macular Edema Secondary to Branch and Central Retinal Vein Occlusion[J]. PLOS ONE,2013,8(7).
APA Feng, Jing,Zhao, Tong,Zhang, Yan,Ma, Yan,&Jiang, Yanrong.(2013).Differences in Aqueous Concentrations of Cytokines in Macular Edema Secondary to Branch and Central Retinal Vein Occlusion.PLOS ONE,8(7).
MLA Feng, Jing,et al."Differences in Aqueous Concentrations of Cytokines in Macular Edema Secondary to Branch and Central Retinal Vein Occlusion".PLOS ONE 8.7(2013).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Feng, Jing]的文章
[Zhao, Tong]的文章
[Zhang, Yan]的文章
百度学术
百度学术中相似的文章
[Feng, Jing]的文章
[Zhao, Tong]的文章
[Zhang, Yan]的文章
必应学术
必应学术中相似的文章
[Feng, Jing]的文章
[Zhao, Tong]的文章
[Zhang, Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。