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Clinical Effect of Maixuekang Capsule on Long-Term Prognosis in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention
Ge Chang-jiang1; Yuan Fei1; Feng Li-xia1; Lv Shu-zheng1; Liu Hong1; Song Xian-tao1; Chen Xin1; Huo Yong2
关键词acute coronary syndrome platelet aggregation inhibitors percutaneous coronary intervention Maixuekang Capsule
刊名CHINESE JOURNAL OF INTEGRATIVE MEDICINE
2014-02-01
DOI10.1007/s11655-013-1580-x
20期:2页:88-93
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]CLOPIDOGREL RESISTANCE ; THROMBIN ; INHIBITION ; RESTENOSIS ; MODEL
英文摘要

Objective: To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI). Methods: A total of 236 patients with acute coronary syndrome, who received successful PCI, were randomly assigned to a trial group (116 cases) and a control group (120 cases) according to random numbers; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent forms. In the trial group, the patients were treated with MKC combined with routine medication, and in the control group the patients were treated with routine medication. The therapeutic course for the two groups was 12 months and the follow-up was 12 months. The levels of ADP-induced platelet aggregation rate and serum high-sensitive C-reactive protein (hs-CRP) were determined before PCI, 12 h and 30 days after PCI. In the meantime, the incidence of cardio-/cerebrovascular events was recorded during the 12-month follow-up. Results: Compared with before PCI, the levels of ADP-induced platelet aggregation rate and serum hs-CRP were significantly higher at 12 h after PCI (P<0.05). They were significantly reduced after 30-day-treatment of MKC, showing statistical differences when compared with those in the control group (P<0.05). During the 12-month follow-up, the incidence of cardio-/cerebrovascular events was significantly lower in the trial group than in the control group (6.9% vs. 12.5%, P<0.01). Conclusions: ADP-induced platelet aggregation function was significantly elevated after PCI. MKC improved the prognosis of patients with acute coronary syndrome, possibly through inhibiting the platelet aggregation, fighting against inflammation, and protecting the vascular endothelial function.

语种英语
WOS记录号WOS:000332860400002
项目编号2006BAI01A02 ; SF-2009-I-09 ; 2013F01
资助机构Key Projects in the National Science and Technology Pillar Program ; Capital Medical Development Fund ; Beijing Anzhen Hospital
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63149
专题北京大学第一临床医学院_心血管内科
作者单位1.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Ge Chang-jiang,Yuan Fei,Feng Li-xia,et al. Clinical Effect of Maixuekang Capsule on Long-Term Prognosis in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2014,20(2):88-93.
APA Ge Chang-jiang.,Yuan Fei.,Feng Li-xia.,Lv Shu-zheng.,Liu Hong.,...&Huo Yong.(2014).Clinical Effect of Maixuekang Capsule on Long-Term Prognosis in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,20(2),88-93.
MLA Ge Chang-jiang,et al."Clinical Effect of Maixuekang Capsule on Long-Term Prognosis in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 20.2(2014):88-93.
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