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学科主题药学
Crystallization at Multiple Sites inside Particles of Amorphous Calcium Phosphate
Wang, Chen-Guang4; Liao, Jia-Wang3; Gou, Bao-Di4; Huang, Jian4; Tang, Rui-Kang1,2; Tao, Jin-Hui1,2; Zhang, Tian-Lan3,4; Wang, Kui4
刊名CRYSTAL GROWTH & DESIGN
2009-06-01
DOI10.1021/cg801069t
9期:6页:2620-2626
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Crystallography ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Crystallography ; Materials Science
关键词[WOS]ELECTROLYTE SOLUTIONS ; LIGHT-SCATTERING ; TRANSFORMATION ; PRECIPITATION ; KINETICS ; CLUSTER
英文摘要

Calcium phosphates are the main minerals in human bone, enamel, atherosclerosis, and dental calculus. Amorphous precursors may play a key role in biomineralization. We studied the formation and transformation of calcium phosphate particles of amorphous phase by stopped-flow spectrophotometry, simultaneous measurements of particle size and solution pH, and high-resolution transmission electron microscopy. Ion pairs and clusters formed in the first few seconds. They then constituted initial amorphous phase containing protonated phosphates and hydrated calcium ions, which was different from that containing Ca(9)(PO(4))(6). Crystalline domains developed at multiple sites inside the primary particles of the amorphous phase. With the consuming of interdomain constituents, these particles partially collapsed, liberating crystallites and inducing rapid precipitation. This study sheds new light on the understanding of crystallization in amorphous phase, as well as the induction period in precipitation kinetics.

语种英语
WOS记录号WOS:000266708600017
项目编号2007CB516806 ; 20571006 ; 20637010 ; 2062007
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Beijing Talent Project
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63150
专题北京大学药学院_化学生物学系
作者单位1.Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
2.Zhejiang Univ, Ctr Biomat & Biopathways, Hangzhou 310027, Zhejiang, Peoples R China
3.Capital Med Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100069, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Chen-Guang,Liao, Jia-Wang,Gou, Bao-Di,et al. Crystallization at Multiple Sites inside Particles of Amorphous Calcium Phosphate[J]. CRYSTAL GROWTH & DESIGN,2009,9(6):2620-2626.
APA Wang, Chen-Guang.,Liao, Jia-Wang.,Gou, Bao-Di.,Huang, Jian.,Tang, Rui-Kang.,...&Wang, Kui.(2009).Crystallization at Multiple Sites inside Particles of Amorphous Calcium Phosphate.CRYSTAL GROWTH & DESIGN,9(6),2620-2626.
MLA Wang, Chen-Guang,et al."Crystallization at Multiple Sites inside Particles of Amorphous Calcium Phosphate".CRYSTAL GROWTH & DESIGN 9.6(2009):2620-2626.
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