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学科主题: 药学
题名:
Crystallization at Multiple Sites inside Particles of Amorphous Calcium Phosphate
作者: Wang, Chen-Guang4; Liao, Jia-Wang3; Gou, Bao-Di4; Huang, Jian4; Tang, Rui-Kang1,2; Tao, Jin-Hui1,2; Zhang, Tian-Lan3,4; Wang, Kui4
刊名: CRYSTAL GROWTH & DESIGN
发表日期: 2009-06-01
DOI: 10.1021/cg801069t
卷: 9, 期:6, 页:2620-2626
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Crystallography ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Crystallography ; Materials Science
关键词[WOS]: ELECTROLYTE SOLUTIONS ; LIGHT-SCATTERING ; TRANSFORMATION ; PRECIPITATION ; KINETICS ; CLUSTER
英文摘要:

Calcium phosphates are the main minerals in human bone, enamel, atherosclerosis, and dental calculus. Amorphous precursors may play a key role in biomineralization. We studied the formation and transformation of calcium phosphate particles of amorphous phase by stopped-flow spectrophotometry, simultaneous measurements of particle size and solution pH, and high-resolution transmission electron microscopy. Ion pairs and clusters formed in the first few seconds. They then constituted initial amorphous phase containing protonated phosphates and hydrated calcium ions, which was different from that containing Ca(9)(PO(4))(6). Crystalline domains developed at multiple sites inside the primary particles of the amorphous phase. With the consuming of interdomain constituents, these particles partially collapsed, liberating crystallites and inducing rapid precipitation. This study sheds new light on the understanding of crystallization in amorphous phase, as well as the induction period in precipitation kinetics.

语种: 英语
所属项目编号: 2007CB516806 ; 20571006 ; 20637010 ; 2062007
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Beijing Talent Project
WOS记录号: WOS:000266708600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63150
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
2.Zhejiang Univ, Ctr Biomat & Biopathways, Hangzhou 310027, Zhejiang, Peoples R China
3.Capital Med Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100069, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Chen-Guang,Liao, Jia-Wang,Gou, Bao-Di,et al. Crystallization at Multiple Sites inside Particles of Amorphous Calcium Phosphate[J]. CRYSTAL GROWTH & DESIGN,2009,9(6):2620-2626.
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