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Cumulative Effects of Variants Identified by Genome-wide Association Studies in IgA Nephropathy
Zhou, Xu-Jie; Qi, Yuan-Yuan; Hou, Ping; Lv, Ji-Cheng; Shi, Su-Fang; Liu, Li-Jun; Zhao, Na; Zhang, Hong1
刊名SCIENTIFIC REPORTS
2014-05-09
DOI10.1038/srep04904
4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GALACTOSE-DEFICIENT IGA1 ; GENETIC RISK SCORE ; GLOMERULAR-FILTRATION-RATE ; CHRONIC KIDNEY-DISEASE ; CARDIOVASCULAR EVENTS ; CHINESE POPULATION ; PROGRESSION ; SUSCEPTIBILITY ; GLYCOSYLATION ; PATHOGENESIS
英文摘要

The effect of genetic markers associated with IgA nephropathy on risk of disease in sub-phenotype and progression is uncertain. Data from 2096 Chinese patients were used to create both un-weighted (uw) and weighted (w) genetic risk score (GRS). The association between GRS with disease susceptibility and clinical parameters were assessed. All nine selected single nucleotide polymorphisms (SNPs) were associated with susceptibility to IgAN. uwGRS and wGRS showed a similar fit in disease associations. With every 1-unit increase in the uwGRS, the disease risk increased by approximately 20%; whereas every one standard deviation increase in the wGRS, disease risk increased by approximately 40% similar to 60%. Association between rs3803800 and serum IgA was replicated, and risk groups in GRSs were associated with increased IgA/IgA1 levels. uwGRS9 >= 16 was an independent predictor for end stage renal disease (ESRD) in IgAN, with a relative risk of 2.52 (p = 6.68 x 10(-3)). In conclusion, we observed that GRSs comprising nine SNPs identified in a GWAS of IgAN were strongly associated with susceptibility to IgAN. The high risk GRS9 group had a high risk of ESRD in follow-up.

语种英语
WOS记录号WOS:000335551200009
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63152
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Div Renal, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Xu-Jie,Qi, Yuan-Yuan,Hou, Ping,et al. Cumulative Effects of Variants Identified by Genome-wide Association Studies in IgA Nephropathy[J]. SCIENTIFIC REPORTS,2014,4.
APA Zhou, Xu-Jie.,Qi, Yuan-Yuan.,Hou, Ping.,Lv, Ji-Cheng.,Shi, Su-Fang.,...&Zhang, Hong.(2014).Cumulative Effects of Variants Identified by Genome-wide Association Studies in IgA Nephropathy.SCIENTIFIC REPORTS,4.
MLA Zhou, Xu-Jie,et al."Cumulative Effects of Variants Identified by Genome-wide Association Studies in IgA Nephropathy".SCIENTIFIC REPORTS 4(2014).
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