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学科主题: 临床医学
题名:
Cumulative Effects of Variants Identified by Genome-wide Association Studies in IgA Nephropathy
作者: Zhou, Xu-Jie; Qi, Yuan-Yuan; Hou, Ping; Lv, Ji-Cheng; Shi, Su-Fang; Liu, Li-Jun; Zhao, Na; Zhang, Hong1
刊名: SCIENTIFIC REPORTS
发表日期: 2014-05-09
DOI: 10.1038/srep04904
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GALACTOSE-DEFICIENT IGA1 ; GENETIC RISK SCORE ; GLOMERULAR-FILTRATION-RATE ; CHRONIC KIDNEY-DISEASE ; CARDIOVASCULAR EVENTS ; CHINESE POPULATION ; PROGRESSION ; SUSCEPTIBILITY ; GLYCOSYLATION ; PATHOGENESIS
英文摘要:

The effect of genetic markers associated with IgA nephropathy on risk of disease in sub-phenotype and progression is uncertain. Data from 2096 Chinese patients were used to create both un-weighted (uw) and weighted (w) genetic risk score (GRS). The association between GRS with disease susceptibility and clinical parameters were assessed. All nine selected single nucleotide polymorphisms (SNPs) were associated with susceptibility to IgAN. uwGRS and wGRS showed a similar fit in disease associations. With every 1-unit increase in the uwGRS, the disease risk increased by approximately 20%; whereas every one standard deviation increase in the wGRS, disease risk increased by approximately 40% similar to 60%. Association between rs3803800 and serum IgA was replicated, and risk groups in GRSs were associated with increased IgA/IgA1 levels. uwGRS9 >= 16 was an independent predictor for end stage renal disease (ESRD) in IgAN, with a relative risk of 2.52 (p = 6.68 x 10(-3)). In conclusion, we observed that GRSs comprising nine SNPs identified in a GWAS of IgAN were strongly associated with susceptibility to IgAN. The high risk GRS9 group had a high risk of ESRD in follow-up.

语种: 英语
所属项目编号: 2012CB517700 ; 81200524 ; 20121000110 ; 20120001120008 ; 81021004
项目资助者: Major State Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; Research Fund of Beijing Municipal Science and Technology for the Outstanding PhD Program ; Foundation of Ministry of Education of China ; Natural Science Fund of China to the Innovation Research Group
WOS记录号: WOS:000335551200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63152
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Div Renal, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Zhou, Xu-Jie,Qi, Yuan-Yuan,Hou, Ping,et al. Cumulative Effects of Variants Identified by Genome-wide Association Studies in IgA Nephropathy[J]. SCIENTIFIC REPORTS,2014,4.
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