IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia
Zhu, Hong-Hu; Qin, Ya-Zhen; Huang, Xiao-Jun
刊名NEW ENGLAND JOURNAL OF MEDICINE
2014-05-08
DOI10.1056/NEJMc1316382
370期:19页:1864-1866
收录类别SCI
文章类型Letter
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]TRIOXIDE ; PML
英文摘要

Although resistance to arsenic trioxide in patients with acute promyelocytic leukemia is very rare, mutations in PML at the site of arsenic binding appears to be the main mechanism of resistance.To the Editor: Acute promyelocytic leukemia (APL) is a highly curable disease. Recently, two randomized trials conducted by Lo-Coco et al.(1) and our group(2) provided strong evidence supporting front-line treatment with arsenic trioxide and all-trans retinoic acid (ATRA) for APL. This treatment has been adopted by the most recent National Comprehensive Cancer Network guidelines.(1) The direct-binding targets of arsenic trioxide in the promyelocytic leukemia protein (PML) B2 domain are required to induce a molecular response in APL.(3),(4) Mutant PML-C212/213 has been shown to lead to resistance to arsenic trioxide in an ex vivo model, but this association has ...

语种英语
WOS记录号WOS:000335997900034
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被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63156
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
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Zhu, Hong-Hu,Qin, Ya-Zhen,Huang, Xiao-Jun. Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia[J]. NEW ENGLAND JOURNAL OF MEDICINE,2014,370(19):1864-1866.
APA Zhu, Hong-Hu,Qin, Ya-Zhen,&Huang, Xiao-Jun.(2014).Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia.NEW ENGLAND JOURNAL OF MEDICINE,370(19),1864-1866.
MLA Zhu, Hong-Hu,et al."Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia".NEW ENGLAND JOURNAL OF MEDICINE 370.19(2014):1864-1866.
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