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学科主题: 临床医学
题名:
Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia
作者: Zhu, Hong-Hu; Qin, Ya-Zhen; Huang, Xiao-Jun
刊名: NEW ENGLAND JOURNAL OF MEDICINE
发表日期: 2014-05-08
DOI: 10.1056/NEJMc1316382
卷: 370, 期:19, 页:1864-1866
收录类别: SCI
文章类型: Letter
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: TRIOXIDE ; PML
英文摘要:

Although resistance to arsenic trioxide in patients with acute promyelocytic leukemia is very rare, mutations in PML at the site of arsenic binding appears to be the main mechanism of resistance.To the Editor: Acute promyelocytic leukemia (APL) is a highly curable disease. Recently, two randomized trials conducted by Lo-Coco et al.(1) and our group(2) provided strong evidence supporting front-line treatment with arsenic trioxide and all-trans retinoic acid (ATRA) for APL. This treatment has been adopted by the most recent National Comprehensive Cancer Network guidelines.(1) The direct-binding targets of arsenic trioxide in the promyelocytic leukemia protein (PML) B2 domain are required to induce a molecular response in APL.(3),(4) Mutant PML-C212/213 has been shown to lead to resistance to arsenic trioxide in an ex vivo model, but this association has ...

语种: 英语
WOS记录号: WOS:000335997900034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63156
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Zhu, Hong-Hu,Qin, Ya-Zhen,Huang, Xiao-Jun. Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia[J]. NEW ENGLAND JOURNAL OF MEDICINE,2014,370(19):1864-1866.
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