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Enhancement of anti-lymphoma immuno-effects mediated by dendritic cells pulsed with heat-stressed and rituximab-coated CD20+lymphoma cells
Ai, Limei; Ren, Hanyun; Shi, Yongjin; Dong, Yujun
关键词B-cell lymphoma rituximab heat shock protein dendritic cells cytotoxic T-lymphocyte
刊名INTERNATIONAL JOURNAL OF HEMATOLOGY
2008-06-01
DOI10.1007/s12185-008-0072-9
87期:5页:459-466
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]CYTOTOXIC T-CELLS ; MONOCLONAL-ANTIBODY ; TUMOR-CELLS ; CTL ; INDUCTION ; ANTI-CD20 ; APOPTOSIS ; CANCER
英文摘要

Rituximab, a CD20-reactive chimeric monoclonal antibody (mAb), induces apoptosis of lymphoma cells and promotes phagocytosis by dendritic cells and produces a cellular immunoresponse by cross-presentation of tumor antigens to T cells. Heat-stressed tumor cells also stimulate dendritic-cell maturation and induce specific cytotoxic T cells against tumor cells by inducing expression of heat-shock proteins. In this study, we used heat-stressed and rituximab-coated CD20+ lymphoma cells as antigens to load onto immature dendritic cells, and found that rituximab-coated CD20+ Raji cells could promote phagocytosis by dendritic cells, and that rituximab-coated or heat-stressed and then rituximab-coated CD20+ Raji cells resulted in increased dendritic cell maturation. Moreover, only CD20+ Raji cells treated with heat and rituximab effectively enhanced the immunostimulating functions of dendritic cells. Thus, our data indicate that rituximab and heat-shock proteins have synergistic effects, resulting in increased induction of cytotoxic T cells against B-cell lymphoma.

语种英语
WOS记录号WOS:000256339800002
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63160
专题北京大学第一临床医学院_血液内科
作者单位Peking Univ First Hosp, Dept Hematol, Beijing 100034, Peoples R China
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GB/T 7714
Ai, Limei,Ren, Hanyun,Shi, Yongjin,et al. Enhancement of anti-lymphoma immuno-effects mediated by dendritic cells pulsed with heat-stressed and rituximab-coated CD20+lymphoma cells[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2008,87(5):459-466.
APA Ai, Limei,Ren, Hanyun,Shi, Yongjin,&Dong, Yujun.(2008).Enhancement of anti-lymphoma immuno-effects mediated by dendritic cells pulsed with heat-stressed and rituximab-coated CD20+lymphoma cells.INTERNATIONAL JOURNAL OF HEMATOLOGY,87(5),459-466.
MLA Ai, Limei,et al."Enhancement of anti-lymphoma immuno-effects mediated by dendritic cells pulsed with heat-stressed and rituximab-coated CD20+lymphoma cells".INTERNATIONAL JOURNAL OF HEMATOLOGY 87.5(2008):459-466.
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