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学科主题: 临床医学
题名:
Enhancement of anti-lymphoma immuno-effects mediated by dendritic cells pulsed with heat-stressed and rituximab-coated CD20+lymphoma cells
作者: Ai, Limei; Ren, Hanyun; Shi, Yongjin; Dong, Yujun
关键词: B-cell lymphoma ; rituximab ; heat shock protein ; dendritic cells ; cytotoxic T-lymphocyte
刊名: INTERNATIONAL JOURNAL OF HEMATOLOGY
发表日期: 2008-06-01
DOI: 10.1007/s12185-008-0072-9
卷: 87, 期:5, 页:459-466
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: CYTOTOXIC T-CELLS ; MONOCLONAL-ANTIBODY ; TUMOR-CELLS ; CTL ; INDUCTION ; ANTI-CD20 ; APOPTOSIS ; CANCER
英文摘要:

Rituximab, a CD20-reactive chimeric monoclonal antibody (mAb), induces apoptosis of lymphoma cells and promotes phagocytosis by dendritic cells and produces a cellular immunoresponse by cross-presentation of tumor antigens to T cells. Heat-stressed tumor cells also stimulate dendritic-cell maturation and induce specific cytotoxic T cells against tumor cells by inducing expression of heat-shock proteins. In this study, we used heat-stressed and rituximab-coated CD20+ lymphoma cells as antigens to load onto immature dendritic cells, and found that rituximab-coated CD20+ Raji cells could promote phagocytosis by dendritic cells, and that rituximab-coated or heat-stressed and then rituximab-coated CD20+ Raji cells resulted in increased dendritic cell maturation. Moreover, only CD20+ Raji cells treated with heat and rituximab effectively enhanced the immunostimulating functions of dendritic cells. Thus, our data indicate that rituximab and heat-shock proteins have synergistic effects, resulting in increased induction of cytotoxic T cells against B-cell lymphoma.

语种: 英语
WOS记录号: WOS:000256339800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63160
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: Peking Univ First Hosp, Dept Hematol, Beijing 100034, Peoples R China

Recommended Citation:
Ai, Limei,Ren, Hanyun,Shi, Yongjin,et al. Enhancement of anti-lymphoma immuno-effects mediated by dendritic cells pulsed with heat-stressed and rituximab-coated CD20+lymphoma cells[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2008,87(5):459-466.
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