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学科主题临床医学
Dynamics of monocyte count: A good predictor for timing of peripheral blood stem cell collection
Yang, Shen-Miao; Chen, Huan; Chen, Yu-Hong; Zhu, Hong-Hu; Zhao, Ting; Liu, Kai-Yan
关键词peripheral blood stem cell mobilization initiation of leukapheresis granulocyte-colony stimulating factor chemotherapy
刊名JOURNAL OF CLINICAL APHERESIS
2012
DOI10.1002/jca.21228
27期:4页:193-199
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]COLONY-STIMULATING FACTOR ; CHEMOTHERAPY-INDUCED MOBILIZATION ; AUTOLOGOUS TRANSPLANTATION ; PROGENITOR CELLS ; GROWTH-FACTORS ; HEMATOPOIETIC PROGENITORS ; APHERESIS ; LYMPHOMA ; YIELD ; CSF
英文摘要

To investigate potential predictive parameters for successful collection of autologous peripheral blood stem cells (PBSC), 60 consecutive first mobilization attempts and 145 leukapheresis procedures for patients with hematologic malignancies (multiple myeloma: n = 20; acute leukemia: n = 27; lymphoma: n = 13) were analyzed. All patients underwent chemotherapy and granulocyte-colony stimulating factor combined mobilization protocols. PBSC collection began when white blood cell (WBC) count rebounded to >1.0 x 109/L. Poor mobilization (PM) was defined as <2.0 x 106/kg of ideal body weight CD34+ cells were collected from at least three leukapheresis procedures. PM incidence was 15% (9/60). On the first apheresis day, CD34+ cell yield was closely associated with the final yield. Failure to reach the first-day target of 0.7 x 106 CD34+ cells/kg was perfectly matched with PM. Circulating WBC and monocyte (MO) counts preleukapheresis had a positive correlation with final CD34+ cell yield. For the first-day apheresis target, receiver operator characteristic (ROC) curve analysis showed that MO count had an area under the curve (AUC) of 0.806 (P = 0.004). An optimal predictive cutoff value for MO count was 1.455 x 109/L with both high sensitivity and specificity of 0.739 and 0.899, respectively. Patients who began leukapheresis with an MO count of =1.455 x 109/L accomplished more successful first-day collections than those of their counterparts (P = 0.021). ROC analysis also showed preapheresis WBC count had a high AUC of 0.768 (P = 0.012). However, we could not find a WBC indicator to initiate leukapheresis. In conclusion, circulating MO count after mobilization is a helpful parameter to determine the optimal time point for starting a PBSC collection. J. Clin. Apheresis 2012. (c) 2012 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000307100700004
项目编号201202017
资助机构Department of Medical Science, Technology and Education, Ministry of Health of the People&prime ; s Republic of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63167
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
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Yang, Shen-Miao,Chen, Huan,Chen, Yu-Hong,et al. Dynamics of monocyte count: A good predictor for timing of peripheral blood stem cell collection[J]. JOURNAL OF CLINICAL APHERESIS,2012,27(4):193-199.
APA Yang, Shen-Miao,Chen, Huan,Chen, Yu-Hong,Zhu, Hong-Hu,Zhao, Ting,&Liu, Kai-Yan.(2012).Dynamics of monocyte count: A good predictor for timing of peripheral blood stem cell collection.JOURNAL OF CLINICAL APHERESIS,27(4),193-199.
MLA Yang, Shen-Miao,et al."Dynamics of monocyte count: A good predictor for timing of peripheral blood stem cell collection".JOURNAL OF CLINICAL APHERESIS 27.4(2012):193-199.
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