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学科主题: 临床医学
题名:
Dynamics of monocyte count: A good predictor for timing of peripheral blood stem cell collection
作者: Yang, Shen-Miao; Chen, Huan; Chen, Yu-Hong; Zhu, Hong-Hu; Zhao, Ting; Liu, Kai-Yan
关键词: peripheral blood stem cell mobilization ; initiation of leukapheresis ; granulocyte-colony stimulating factor ; chemotherapy
刊名: JOURNAL OF CLINICAL APHERESIS
发表日期: 2012
DOI: 10.1002/jca.21228
卷: 27, 期:4, 页:193-199
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: COLONY-STIMULATING FACTOR ; CHEMOTHERAPY-INDUCED MOBILIZATION ; AUTOLOGOUS TRANSPLANTATION ; PROGENITOR CELLS ; GROWTH-FACTORS ; HEMATOPOIETIC PROGENITORS ; APHERESIS ; LYMPHOMA ; YIELD ; CSF
英文摘要:

To investigate potential predictive parameters for successful collection of autologous peripheral blood stem cells (PBSC), 60 consecutive first mobilization attempts and 145 leukapheresis procedures for patients with hematologic malignancies (multiple myeloma: n = 20; acute leukemia: n = 27; lymphoma: n = 13) were analyzed. All patients underwent chemotherapy and granulocyte-colony stimulating factor combined mobilization protocols. PBSC collection began when white blood cell (WBC) count rebounded to >1.0 x 109/L. Poor mobilization (PM) was defined as <2.0 x 106/kg of ideal body weight CD34+ cells were collected from at least three leukapheresis procedures. PM incidence was 15% (9/60). On the first apheresis day, CD34+ cell yield was closely associated with the final yield. Failure to reach the first-day target of 0.7 x 106 CD34+ cells/kg was perfectly matched with PM. Circulating WBC and monocyte (MO) counts preleukapheresis had a positive correlation with final CD34+ cell yield. For the first-day apheresis target, receiver operator characteristic (ROC) curve analysis showed that MO count had an area under the curve (AUC) of 0.806 (P = 0.004). An optimal predictive cutoff value for MO count was 1.455 x 109/L with both high sensitivity and specificity of 0.739 and 0.899, respectively. Patients who began leukapheresis with an MO count of =1.455 x 109/L accomplished more successful first-day collections than those of their counterparts (P = 0.021). ROC analysis also showed preapheresis WBC count had a high AUC of 0.768 (P = 0.012). However, we could not find a WBC indicator to initiate leukapheresis. In conclusion, circulating MO count after mobilization is a helpful parameter to determine the optimal time point for starting a PBSC collection. J. Clin. Apheresis 2012. (c) 2012 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 201202017
项目资助者: Department of Medical Science, Technology and Education, Ministry of Health of the People&prime ; s Republic of China
WOS记录号: WOS:000307100700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63167
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Yang, Shen-Miao,Chen, Huan,Chen, Yu-Hong,et al. Dynamics of monocyte count: A good predictor for timing of peripheral blood stem cell collection[J]. JOURNAL OF CLINICAL APHERESIS,2012,27(4):193-199.
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