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学科主题临床医学
Endogenous generation of sulfur dioxide in rat tissues
Luo, Liman1; Chen, Stella2; Jin, Hongfang1; Tang, Chaoshu3,4; Du, Junbao1,4
关键词Sulfur dioxide Aspartate aminotransferase Cysteine dioxygenase
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2011-11-11
DOI10.1016/j.bbrc.2011.10.012
415期:1页:61-67
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]HYDROGEN-SULFIDE ; SERUM SULFITE ; CONTAINING GASES ; DERIVATIVES ; EXPRESSION ; STRESS ; SYSTEM ; SIGNAL
英文摘要

While sulfur dioxide (SO2) has been previously known for its toxicological effects, it is now known to be produced endogenously in mammals from sulfur-containing amino acid L-cysteine. L-cysteine is catalyzed by cysteine dioxygenase (CDO) to L-cysteinesulfinate, which converts to beta-sulfinylpyruvate through transamination by aspartate aminotransferase (AAT), and finally spontaneously decomposes to pyruvate and SO2. The present study explored endogenous SO2 production, and MT and CDO distribution in different rat tissue. SO2 content was highest in stomach, followed by tissues in the right ventricle, left ventricle, cerebral gray matter, pancreas, lung, cerebral white matter, renal medulla, spleen, renal cortex and liver. AAT activity and AAT1 mRNA expression were highest in the left ventricle, while AAT1 protein expression was highest in the right ventricle. AAT2 and CDO mRNA expressions were both highest in liver tissue. AAT2 protein expression was highest in the renal medulla, but COO protein expression was highest in liver tissue. In all tissues, AAT1 and AAT2 were mainly distributed in the cytoplasm rather than the nucleus. These observed differences among tissues endogenously generating SO2 and associated enzymes are important in implicating the discovery of SO2 as a novel endogenous signaling molecule. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000297385000011
项目编号2011CB503904 ; 2012CB517806 ; 30821001 ; 81070111 ; 7112130
资助机构Major Basic Research Development Program of People&prime ; s Republic of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63171
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Univ Calif San Diego, Dept Biol Sci, La Jolla, CA 92093 USA
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Luo, Liman,Chen, Stella,Jin, Hongfang,et al. Endogenous generation of sulfur dioxide in rat tissues[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,415(1):61-67.
APA Luo, Liman,Chen, Stella,Jin, Hongfang,Tang, Chaoshu,&Du, Junbao.(2011).Endogenous generation of sulfur dioxide in rat tissues.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,415(1),61-67.
MLA Luo, Liman,et al."Endogenous generation of sulfur dioxide in rat tissues".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 415.1(2011):61-67.
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