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学科主题: 临床医学
题名:
Endogenous generation of sulfur dioxide in rat tissues
作者: Luo, Liman1; Chen, Stella2; Jin, Hongfang1; Tang, Chaoshu3,4; Du, Junbao1,4
关键词: Sulfur dioxide ; Aspartate aminotransferase ; Cysteine dioxygenase
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2011-11-11
DOI: 10.1016/j.bbrc.2011.10.012
卷: 415, 期:1, 页:61-67
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: HYDROGEN-SULFIDE ; SERUM SULFITE ; CONTAINING GASES ; DERIVATIVES ; EXPRESSION ; STRESS ; SYSTEM ; SIGNAL
英文摘要:

While sulfur dioxide (SO2) has been previously known for its toxicological effects, it is now known to be produced endogenously in mammals from sulfur-containing amino acid L-cysteine. L-cysteine is catalyzed by cysteine dioxygenase (CDO) to L-cysteinesulfinate, which converts to beta-sulfinylpyruvate through transamination by aspartate aminotransferase (AAT), and finally spontaneously decomposes to pyruvate and SO2. The present study explored endogenous SO2 production, and MT and CDO distribution in different rat tissue. SO2 content was highest in stomach, followed by tissues in the right ventricle, left ventricle, cerebral gray matter, pancreas, lung, cerebral white matter, renal medulla, spleen, renal cortex and liver. AAT activity and AAT1 mRNA expression were highest in the left ventricle, while AAT1 protein expression was highest in the right ventricle. AAT2 and CDO mRNA expressions were both highest in liver tissue. AAT2 protein expression was highest in the renal medulla, but COO protein expression was highest in liver tissue. In all tissues, AAT1 and AAT2 were mainly distributed in the cytoplasm rather than the nucleus. These observed differences among tissues endogenously generating SO2 and associated enzymes are important in implicating the discovery of SO2 as a novel endogenous signaling molecule. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2011CB503904 ; 2012CB517806 ; 30821001 ; 81070111 ; 7112130
项目资助者: Major Basic Research Development Program of People&prime ; s Republic of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000297385000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63171
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Univ Calif San Diego, Dept Biol Sci, La Jolla, CA 92093 USA
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China

Recommended Citation:
Luo, Liman,Chen, Stella,Jin, Hongfang,et al. Endogenous generation of sulfur dioxide in rat tissues[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,415(1):61-67.
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