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学科主题: 基础医学
题名:
Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference
作者: Lv, Xiu-Fang; Xu, Ya; Han, Ji-Sheng; Cui, Cai-Lian1
关键词: Activity regulated cytoskeleton-associated protein/activity-regulated gene (Arc/Arg3.1) ; Morphine ; Conditioned place preference (CPP) ; Nucleus accumbens (NAc) ; Acquisition ; Expression ; Reinstatement
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2011-09-30
DOI: 10.1016/j.bbr.2011.04.029
卷: 223, 期:1, 页:182-191
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: IMMEDIATE-EARLY GENE ; LONG-TERM-MEMORY ; SYNAPTIC PLASTICITY ; EXTENDED AMYGDALA ; SEEKING BEHAVIOR ; FOS EXPRESSION ; MESSENGER-RNA ; RAT STRIATUM ; ARC PROTEIN ; CORE
英文摘要:

Activity-regulated cytoskeleton-associated protein (Arc), also known as activity-regulated gene 3.1 (Arg3.1), is an immediate early gene whose mRNA is selectively targeted to recently activated synaptic sites, where it is translated and enriched. This unique feature suggests a role for Arc/Arg3.1 in coupling synaptic activity to protein synthesis, leading to synaptic plasticity. Although the Arc/Arg3.1 gene has been shown to be induced by a variety of abused drugs and its protein has been implicated in diverse forms of long-term memory, relatively little is known about its role in drug-induced reward memory. In this study, we investigated the potential role of Arc/Arg3.1 protein expression in reward-related associative learning and memory using morphine-induced conditioned place preference (CPP) in rats. We found that (1) intraperitoneal (i.p.) injection of morphine (10 mg/kg) increased Arc/Arg3.1 protein levels after 2 h in the NAc core but not in the NAc shell. (2) In CPP experiments, Arc/Arg3.1 protein was increased in the NAc shell of rats following both morphine conditioning and the CPP expression test compared to rats that received the conditioning without the test or those that did not receive morphine conditioning. (3) Microinjection of Arc/Arg3.1 antisense oligodeoxynucleotide (AS) into the NAc core inhibited the acquisition, expression and reinstatement of morphine CPP;,however, intra-NAc shell infusions of the AS only blocked the expression of CPP. These findings suggest that expression of the Arc/Arg3.1 protein in the NAc core is required for the acquisition, context-induced retrieval and reinstatement of morphine-associated reward memory, whereas Arc/Arg3.1 protein expression in the NAc shell is only critical for the context-induced retrieval of memory. As a result, Arc/Arg3.1 may be a potential therapeutic target for the prevention of drug abuse or the relapse of drug use. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30770690 ; 2009CB522003
项目资助者: National Natural Science Foundation ; National Basic Research Program
WOS记录号: WOS:000292587700024
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63173
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ Hlth Sci Ctr, Minist Educ, Key Lab Neurosci, Dept Neurobiol, Beijing 100191, Peoples R China
3.Minist Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Lv, Xiu-Fang,Xu, Ya,Han, Ji-Sheng,et al. Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference[J]. BEHAVIOURAL BRAIN RESEARCH,2011,223(1):182-191.
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