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学科主题: 临床医学
题名:
Cobalt-60 gamma radiation increased the nitric oxide generation in cultured rat vascular smooth muscle cells
作者: Zhong, GZ; Chen, FR; Bu, DF; Wang, SH; Pang, YZ; Tang, CS
关键词: radiation nitric oxide ; inducible nitric oxide synthase
刊名: LIFE SCIENCES
发表日期: 2004-05-07
DOI: 10.1016/j.lfs.2003.08.049
卷: 74, 期:25, 页:3055-3063
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: ENDOTHELIUM-DEPENDENT VASODILATION ; BETA-IRRADIATION ; RESTENOSIS ; ARTERY ; ACTIVATION ; EXPRESSION ; GENE
英文摘要:

Radiation is a promising and new treatment for restenosis following angioplasty. Nitric oxide has been proposed as a potential "anti-restenotic" molecule. We radiated the cultured rat vascular smooth muscle cells with Cobalt-60 Gamma radiation at doses of 14 and 25Gy and observed nitrite production, cGMP content, L-arginine uptake, inducible nitric oxide synthase (iNOS) activity, and the gene expression of iNOS. Results showed that radiation at doses of 14 and 25Gy increased cGMP content by 92.4% and 86.4%, respectively. Radiation at the dose of 25Gy increased the iNOS activity and nitrite content, but radiation at the dose of 14Gy had no significant effect on iNOS activity and NO production. Both doses of radiation significantly decreased the L-arginine transport. Radiation at the doses of 14 and 25Gy increased iNOS gene expression significantly, which was consistent with the effect of radiation on NOS activity. In conclusion, radiation induces the NO generation by up-regulating the NOS activity. (C) 2004 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000221020100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63179
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100034, Peoples R China
3.Peking Univ, Cardiovasc Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Zhong, GZ,Chen, FR,Bu, DF,et al. Cobalt-60 gamma radiation increased the nitric oxide generation in cultured rat vascular smooth muscle cells[J]. LIFE SCIENCES,2004,74(25):3055-3063.
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