IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Cobalt-60 gamma radiation increased the nitric oxide generation in cultured rat vascular smooth muscle cells
Zhong, GZ; Chen, FR; Bu, DF; Wang, SH; Pang, YZ; Tang, CS
关键词radiation nitric oxide inducible nitric oxide synthase
刊名LIFE SCIENCES
2004-05-07
DOI10.1016/j.lfs.2003.08.049
74期:25页:3055-3063
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]ENDOTHELIUM-DEPENDENT VASODILATION ; BETA-IRRADIATION ; RESTENOSIS ; ARTERY ; ACTIVATION ; EXPRESSION ; GENE
英文摘要

Radiation is a promising and new treatment for restenosis following angioplasty. Nitric oxide has been proposed as a potential "anti-restenotic" molecule. We radiated the cultured rat vascular smooth muscle cells with Cobalt-60 Gamma radiation at doses of 14 and 25Gy and observed nitrite production, cGMP content, L-arginine uptake, inducible nitric oxide synthase (iNOS) activity, and the gene expression of iNOS. Results showed that radiation at doses of 14 and 25Gy increased cGMP content by 92.4% and 86.4%, respectively. Radiation at the dose of 25Gy increased the iNOS activity and nitrite content, but radiation at the dose of 14Gy had no significant effect on iNOS activity and NO production. Both doses of radiation significantly decreased the L-arginine transport. Radiation at the doses of 14 and 25Gy increased iNOS gene expression significantly, which was consistent with the effect of radiation on NOS activity. In conclusion, radiation induces the NO generation by up-regulating the NOS activity. (C) 2004 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000221020100001
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63179
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100034, Peoples R China
3.Peking Univ, Cardiovasc Res Inst, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhong, GZ,Chen, FR,Bu, DF,et al. Cobalt-60 gamma radiation increased the nitric oxide generation in cultured rat vascular smooth muscle cells[J]. LIFE SCIENCES,2004,74(25):3055-3063.
APA Zhong, GZ,Chen, FR,Bu, DF,Wang, SH,Pang, YZ,&Tang, CS.(2004).Cobalt-60 gamma radiation increased the nitric oxide generation in cultured rat vascular smooth muscle cells.LIFE SCIENCES,74(25),3055-3063.
MLA Zhong, GZ,et al."Cobalt-60 gamma radiation increased the nitric oxide generation in cultured rat vascular smooth muscle cells".LIFE SCIENCES 74.25(2004):3055-3063.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhong, GZ]的文章
[Chen, FR]的文章
[Bu, DF]的文章
百度学术
百度学术中相似的文章
[Zhong, GZ]的文章
[Chen, FR]的文章
[Bu, DF]的文章
必应学术
必应学术中相似的文章
[Zhong, GZ]的文章
[Chen, FR]的文章
[Bu, DF]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。