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Flow-Mediated Vasodilation and Endothelium Function in Children With Postural Orthostatic Tachycardia Syndrome
Liao, Ying1; Chen, Stella4; Liu, Xueqin1; Zhang, Qingyou1; Ai, Yi2; Wang, Li2; Jin, Hongfang1; Tang, Chaoshu3; Du, Junbao1
刊名AMERICAN JOURNAL OF CARDIOLOGY
2010-08-01
DOI10.1016/j.amjcard.2010.03.034
106期:3页:378-382
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]NITRIC-OXIDE SYNTHASE ; VON-WILLEBRAND-FACTOR ; DYSFUNCTION ; DILATATION ; SYNCOPE ; CELLS
英文摘要

The study was designed to explore flow-mediated vasodilation (FMD) and endothelium function in children with postural orthostatic tachycardia syndrome (POTS). The patient group consisted of 46 children 12 +/- 3 years of age who were diagnosed with POTS from June 2008 to January 2009 by head-up test or head-up tilt test at Peking University First Hospital. Twenty healthy children 12 +/- 4 years of age were selected for the control group. Plasma concentrations of nitric oxide (NO) and activity of NO synthase (NOS) were determined in the patient and control groups. FMD of each participant′s brachial artery was measured using color Doppler vascular ultrasound and a comparison of FMDs and plasma NO and NOS activities between the 2 groups was done using independent t test. No significant differences were found between the POTS and control groups in age, sex ratio, height, body weight, baseline blood pressure, heart rate, and baseline brachial artery diameter. Patients in the POTS group had larger FMD (10.8 +/- 4.4%) than children in the control group (5.7 +/- 2.2%), and this difference was significant (p <0.01). Plasma NO and NOS levels were significantly higher in the POTS group than in the control group (NO 74 +/- 19 mu mol/L in POTS group vs 62 +/- 6 mu mol/L in control group, p <0.01; NOS 21 +/- 3 U/mL in POTS group vs 15 +/- 1 U/mL in control group, p <0.01). In addition, there was a significant correlation between FMD and the NOS activity. In conclusion, augmented FMD and abnormal function of vascular endothelium may play an important role in POTS in children. (C) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;106:378-382)

语种英语
WOS记录号WOS:000280697700014
项目编号2008A007 ; 2006CB503807 ; 2007-2003
资助机构Beijing Scientific and Technologic Star Program, Beijing, People&prime ; s Republic of China ; Changjiang Scholar Program ; Major Basic Research Project of China, China ; Capital Medical Development Foundation, Beijing, Peoples Republic of China
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63184
专题北京大学第一临床医学院_儿科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat Ultrasound, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
4.Univ Calif San Diego, La Jolla, CA 92093 USA
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Liao, Ying,Chen, Stella,Liu, Xueqin,et al. Flow-Mediated Vasodilation and Endothelium Function in Children With Postural Orthostatic Tachycardia Syndrome[J]. AMERICAN JOURNAL OF CARDIOLOGY,2010,106(3):378-382.
APA Liao, Ying.,Chen, Stella.,Liu, Xueqin.,Zhang, Qingyou.,Ai, Yi.,...&Du, Junbao.(2010).Flow-Mediated Vasodilation and Endothelium Function in Children With Postural Orthostatic Tachycardia Syndrome.AMERICAN JOURNAL OF CARDIOLOGY,106(3),378-382.
MLA Liao, Ying,et al."Flow-Mediated Vasodilation and Endothelium Function in Children With Postural Orthostatic Tachycardia Syndrome".AMERICAN JOURNAL OF CARDIOLOGY 106.3(2010):378-382.
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