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Microbial transformation of curcumin by Rhizopus chinensis
Zhang, Xing1,2; Ye, Min1; Li, Rui1; Yin, Jun2; Guo, De-An1
关键词Curcumin biotransformation glucosylation fungi Rhizopus chinensis
刊名BIOCATALYSIS AND BIOTRANSFORMATION
2010-12-01
DOI10.3109/10242422.2010.532870
28期:5-6页:380-386
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
关键词[WOS]TANDEM MASS-SPECTROMETRY ; ELECTROSPRAY-IONIZATION ; CANCER
英文摘要

Curcumin (1) is a potent antioxidant and antitumor natural product. In spite of its efficacy and safety, its clinical use is hindered mainly by poor water solubility and bioavailability. Structural modification to introduce hydrophilic functions is a promising approach to resolve this problem. In the present study we first found that curcumin could be efficiently converted into glucosides by filamentous fungi including Rhizopus chinensis IFFI 03043, Absidia coerulea AS 3.3389 and Cunninghamella elegans AS 3.1207. Curcumin 4′-O-beta-D-glucoside (2), together with hexahydrocurcumin (3), was isolated from a preparative-scale biotransformation with R. chinensis IFFI 03043 and characterized fully by NMR and MS. A time-course study revealed that curcumin could be efficiently converted into curcumin 4′-O-beta-D-glucoside within 8 h when administered at 0.05 mmol L(-1) and the productivity was 57%. Additionally, the biotransformation products of curcumin by different fungal strains were analyzed by LC/MS. At least 15 metabolites were detected, and the predominant biotransformation reaction was glucosylation. This study provides a simple, efficient and less expensive approach for the preparation of curcumin glucosides. The introduction of the glucosyl function might be able to enhance the bioavailability of curcumin.

语种英语
WOS记录号WOS:000285554000010
项目编号7102103 ; 2009B02
资助机构Beijing Natural Science Foundation ; Beijing NOVA Program
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63186
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学第一临床医学院_手术室
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xing,Ye, Min,Li, Rui,et al. Microbial transformation of curcumin by Rhizopus chinensis[J]. BIOCATALYSIS AND BIOTRANSFORMATION,2010,28(5-6):380-386.
APA Zhang, Xing,Ye, Min,Li, Rui,Yin, Jun,&Guo, De-An.(2010).Microbial transformation of curcumin by Rhizopus chinensis.BIOCATALYSIS AND BIOTRANSFORMATION,28(5-6),380-386.
MLA Zhang, Xing,et al."Microbial transformation of curcumin by Rhizopus chinensis".BIOCATALYSIS AND BIOTRANSFORMATION 28.5-6(2010):380-386.
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