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学科主题: 药学
题名:
Microbial transformation of curcumin by Rhizopus chinensis
作者: Zhang, Xing1,2; Ye, Min1; Li, Rui1; Yin, Jun2; Guo, De-An1
关键词: Curcumin ; biotransformation ; glucosylation ; fungi ; Rhizopus chinensis
刊名: BIOCATALYSIS AND BIOTRANSFORMATION
发表日期: 2010-12-01
DOI: 10.3109/10242422.2010.532870
卷: 28, 期:5-6, 页:380-386
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
关键词[WOS]: TANDEM MASS-SPECTROMETRY ; ELECTROSPRAY-IONIZATION ; CANCER
英文摘要:

Curcumin (1) is a potent antioxidant and antitumor natural product. In spite of its efficacy and safety, its clinical use is hindered mainly by poor water solubility and bioavailability. Structural modification to introduce hydrophilic functions is a promising approach to resolve this problem. In the present study we first found that curcumin could be efficiently converted into glucosides by filamentous fungi including Rhizopus chinensis IFFI 03043, Absidia coerulea AS 3.3389 and Cunninghamella elegans AS 3.1207. Curcumin 4′-O-beta-D-glucoside (2), together with hexahydrocurcumin (3), was isolated from a preparative-scale biotransformation with R. chinensis IFFI 03043 and characterized fully by NMR and MS. A time-course study revealed that curcumin could be efficiently converted into curcumin 4′-O-beta-D-glucoside within 8 h when administered at 0.05 mmol L(-1) and the productivity was 57%. Additionally, the biotransformation products of curcumin by different fungal strains were analyzed by LC/MS. At least 15 metabolites were detected, and the predominant biotransformation reaction was glucosylation. This study provides a simple, efficient and less expensive approach for the preparation of curcumin glucosides. The introduction of the glucosyl function might be able to enhance the bioavailability of curcumin.

语种: 英语
所属项目编号: 7102103 ; 2009B02
项目资助者: Beijing Natural Science Foundation ; Beijing NOVA Program
WOS记录号: WOS:000285554000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63186
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China

Recommended Citation:
Zhang, Xing,Ye, Min,Li, Rui,et al. Microbial transformation of curcumin by Rhizopus chinensis[J]. BIOCATALYSIS AND BIOTRANSFORMATION,2010,28(5-6):380-386.
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