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学科主题: 药学
题名:
A Versatile Approach to N-Alkylated 1,4-Dideoxy-1,4-imino-D-arabinitols and 1,4-Dideoxy-1,4-imino-L-xylitols
作者: Wang, Guan-Nan; Yang, Lin; Zhang, Li-He; Ye, Xin-Shan1
刊名: JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2011-04-01
DOI: 10.1021/jo1020322
卷: 76, 期:7, 页:2001-2009
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: NATURALLY-OCCURRING IMINOSUGARS ; VIRAL DIARRHEA VIRUS ; GLYCOSIDASE INHIBITORS ; ASYMMETRIC-SYNTHESIS ; BIOLOGICAL-ACTIVITY ; NATURAL OCCURRENCE ; PYRROLIDINES ; DERIVATIVES ; AGENTS ; SUGARS
英文摘要:

A versatile and concise synthesis of N-alkylated 1,4-dideoxy-1,4-imino-D-arabinitol and 1,4-dideoxy-1,4-imino-L-xylitol derivatives is described. These were prepared using pseudohemiketal lactams as key intermediates, which in turn were obtained from sucrose. The key intermediates were prepared by a diastereospecific tandem reaction which facilitated the introduction of various substituents on the nitrogen atom of the iminosugars.

语种: 英语
所属项目编号: 90713010 ; 2009ZX09501-011
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000288692000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63194
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Guan-Nan,Yang, Lin,Zhang, Li-He,et al. A Versatile Approach to N-Alkylated 1,4-Dideoxy-1,4-imino-D-arabinitols and 1,4-Dideoxy-1,4-imino-L-xylitols[J]. JOURNAL OF ORGANIC CHEMISTRY,2011,76(7):2001-2009.
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