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学科主题: 公共卫生
题名:
Predictors of Visual Response to Intravitreal Bevacizumab for Treatment of Neovascular Age-Related Macular Degeneration
作者: Fang, Kai1; Tian, Jun1; Qing, Xueying1; Li, Shuai1; Hou, Jing2,3; Li, Juan4; Yu, Wenzhen2,3; Chen, Dafang1; Hu, Yonghua1; Li, Xiaoxin2,3
刊名: JOURNAL OF OPHTHALMOLOGY
发表日期: 2013
DOI: 10.1155/2013/676049
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Ophthalmology
研究领域[WOS]: Research & Experimental Medicine ; Ophthalmology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; CHOROIDAL NEOVASCULARIZATION ; CIGARETTE-SMOKING ; RANIBIZUMAB TREATMENT ; SUBGROUP ANALYSIS ; EPITHELIAL-CELLS ; RISK-FACTORS ; FACTOR VEGF ; ASSOCIATION ; EXPRESSION
英文摘要:

Purpose. To identify the predictors of visual response to the bevacizumab treatment of neovascular age-related macular degeneration (AMD). Design. A cohort study within the Neovascular AMD Treatment Trial Using Bevacizumab (NATTB). Methods. This was a multicenter trial including 144 participants from the NATTB study. Visual outcomes measured by change in visual acuity (VA) score, proportion gaining >= 15 letters, and change in central retinal thickness (CRT) were compared among groups according to the baseline, demographic, and ocular characteristics and genotypes. Results. Mean change in the VA score was 9.2 +/- 2.3 SD letters with a total of 46 participants (31.9%) gaining >= 15 letters. Change in median CRT was -81.5 mu m. Younger age, lower baseline VA score, shorter duration of neovascular AMD, and TT genotype in rs10490924 were significantly associated with greater VA score improvement (P = 0.028, P < 0.001, P = 0.02, and P = 0.039, resp.). Lower baseline VA score and TT genotype in rs10490924 were significantly associated with a higher likelihood of gaining >= 15 letters (P = 0.028, and P = 0.021, resp.). Conclusions. Baseline VA and genotype of rs10490924 were both important predictors for visual response to bevacizumab at 6 months. This trial is registered with the Registration no. NCT01306591.

语种: 英语
所属项目编号: 2006BAI02B05
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China, Beijing, China
WOS记录号: WOS:000324200500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63195
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100044, Peoples R China
3.Minist Educ, Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China
4.Beijing Ctr Dis Control & Prevent, Inst Immunoprophylaxis, Beijing 100013, Peoples R China

Recommended Citation:
Fang, Kai,Tian, Jun,Qing, Xueying,et al. Predictors of Visual Response to Intravitreal Bevacizumab for Treatment of Neovascular Age-Related Macular Degeneration[J]. JOURNAL OF OPHTHALMOLOGY,2013.
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