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IR@PKUHSC  > 北京大学临床肿瘤学院  > 病理科  > 期刊论文
学科主题: 临床医学
题名:
Overexpression of gastrin and c-met protein involved in human gastric carcinomas and intestinal metaplasia
作者: Tang, ZB; Zhao, M; Jiafu, JF; Yang, GB; Hu, FL; He, JS; Shen, H; Gao, Z; Zhao, A; Li, JY; Lu, YY
关键词: gastrin ; c-met protein ; gastric carcinomas ; intestinal metaplasia
刊名: ONCOLOGY REPORTS
发表日期: 2004-02-01
卷: 11, 期:2, 页:333-339
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TISSUE MICROARRAY TECHNOLOGY ; TYROSINE KINASE RECEPTOR ; HEPATOCYTE GROWTH-FACTOR ; CELL LUNG-CANCER ; TUMOR-CELLS ; COLON-CANCER ; EGF RECEPTOR ; HUMAN-BREAST ; CLINICAL-SIGNIFICANCE ; GENE AMPLIFICATION
英文摘要:

Many studies have investigated the expression of c-met and c-erbB2 protein in human gastric adenocarcinomas, but the expression of gastrin protein in human gastric cancer and the relationship between gastrin and c-met are unknown. We have constructed a tissue microarray containing 408 formalin-fixed and paraffin-embedded human tissue blocks, including tissues containing intestinal metaplasia (IM, n=72) and primary tumors (n=232), as well as normal gastric mucosa (n=104) from patients with gastric cancer. Immunohistochemistry (IHC) was used for detecting gastrin, c-met and c-erbB2 proteins. Gastrin was detected in 13.5% (7/52) and c-met in 15.3% (11/72) of IM cases. In gastric carcinomas, 48.4% (103/213) of cases expressed gastrin, 68.8% (148/215) expressed c-met, and 5.5% (11/200) expressed c-erbB2. Gastrin and c-met protein expression were significantly higher in gastric tumor tissue than in IM (P<0.0001). Overexpression of c-erbB2 protein was detected in gastric carcinomas but not in normal gastric mucosa (P<0.05). Expression of gastrin and c-met protein was associated (P<0.01), but no siginificant difference was found on the changes of gastrin, c-met and c-erbB2 expression in gastric cancer with tumor stage, grade of differentiation or tumor type. These results indicate that gastrin and c-met play a role in the early process during malignant transformation of the gastric mucosa.

语种: 英语
WOS记录号: WOS:000188233600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63199
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Surg, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Dept Pathol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Beijing Lab Mol Oncol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China

Recommended Citation:
Tang, ZB,Zhao, M,Jiafu, JF,et al. Overexpression of gastrin and c-met protein involved in human gastric carcinomas and intestinal metaplasia[J]. ONCOLOGY REPORTS,2004,11(2):333-339.
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