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学科主题: 临床医学
题名:
Macrolide Therapy Decreases Chronic Obstructive Pulmonary Disease Exacerbation: A Meta-Analysis
作者: Yao, Guo-Yan1,2; Ma, Yan-Liang1; Zhang, Mo-Qin1; Gao, Zhan-Cheng1
关键词: Chronic obstructive pulmonary disease ; Exacerbation ; Macrolide ; Meta-analysis
刊名: RESPIRATION
发表日期: 2013
DOI: 10.1159/000350828
卷: 86, 期:3, 页:254-260
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: LONG-TERM ; DIFFUSE PANBRONCHIOLITIS ; ERYTHROMYCIN ; COPD ; AZITHROMYCIN ; ANTIBIOTICS ; FLUTICASONE ; PREVENTION ; SALMETEROL ; SURVIVAL
英文摘要:

Background: Macrolide antibiotics have anti-inflammatory effects, and long-term administration may reduce chronic obstructive pulmonary disease (COPD) exacerbations. Objective: To investigate the effects of long-term treatment of macrolide therapy for COPD. Methods: We searched the PubMed and Embase databases to identify randomized controlled trials that evaluated the effect of macrolide therapy (of at least 2 weeks) for COPD. The primary outcome assessed was the frequency of acute exacerbations during follow-up. Results: Six trials involving 1,485 COPD patients were included in the analysis. Analysis of the pooled data of all 6 trials showed that macrolide administration reduced the frequency of acute exacerbations of COPD [risk ratio (RR) = 0.62; 95% CI 0.43-0.89, p = 0.01]. Subgroup analysis showed that only erythromycin might be associated with decreased COPD exacerbations (erythromycin: p = 0.04, azithromycin: p = 0.22, clarithromycin: p = 0.18). Moreover, macrolide therapy for 3 months did not significantly reduce the number of exacerbations (p = 0.18), whereas a beneficial effect was conclusive in the 6-month (p = 0.009) and 12-month (p = 0.03) treatment subgroups. In addition, nonfatal adverse events were more frequent in the macrolide treatment groups than in the controls (RR = 1.32; 95% CI 1.06-1.64, p = 0.01). However, related clinical factors had no influence on the overall result (p = 0.19). There was no publication bias among the included trials. Conclusions: Macrolide therapy was effective and safe in decreasing the frequency of exacerbations in patients with COPD. Treatment might provide a significant benefit but only when therapy lasts more than 6 months. Copyright (C) 2013 S. Karger AG, Basel

语种: 英语
WOS记录号: WOS:000324694300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63201
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Fengtai Hosp, Dept Resp Med, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China

Recommended Citation:
Yao, Guo-Yan,Ma, Yan-Liang,Zhang, Mo-Qin,et al. Macrolide Therapy Decreases Chronic Obstructive Pulmonary Disease Exacerbation: A Meta-Analysis[J]. RESPIRATION,2013,86(3):254-260.
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