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Antiaging Effect of Cordyceps sinensis Extract
Ji, Deng-Bo1; Ye, Jia1; Li, Chang-Ling1; Wang, Yu-Hwa1; Zhao, Jiong1; Cai, Shao-Qing2
关键词Cordyceps sinensis extract antiaging antioxidation
刊名PHYTOTHERAPY RESEARCH
2009
DOI10.1002/ptr.2576
23期:1页:116-122
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]D-GALACTOSE ; ANTITUMOR-ACTIVITY ; MICE ; MEMORY ; BRAIN ; MOUSE ; POLYSACCHARIDES ; DAMAGE ; ASSAY ; RATS
英文摘要

This experiment studied the effect of Cordyceps sinensis extract (CSE) on mice aged by D-galactose and castrated rats to analyse its antiaging effect. Water maze and step-down type avoidance tests were used to examine the effect of CSE on learning and memory. CSE shortened escape latency, prolonged step-down latency and decreased the number of errors in mice aged by D-galactose. The effect of CSE on the sexual function of castrated rats was evaluated by measuring the penis erection latency, mount latency and ejaculation latency. CSE appeared to shorten penis erection latency and mount latency in castrated rats. The study also measured the effect of CSE on the activity of age-related enzymes. The results showed that CSE improved the activity of superoxide dismutase, glutathione peroxidase and catalase and lowered the level of lipid peroxidation and monoamine oxidase activity in the aged mice. The study demonstrated that CSE can improve the brain function and antioxidative enzyme activity in mice with D-galactose-induced senescence and promote sexual function in castrated rats. All of these findings suggest that CSE has an antiaging effect. Copyright (c) 2008 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000262567200019
项目编号39470058
资助机构Nature Science Foundation of China (NSFC)
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63205
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学药学院_分子与细胞药理学系
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ji, Deng-Bo,Ye, Jia,Li, Chang-Ling,et al. Antiaging Effect of Cordyceps sinensis Extract[J]. PHYTOTHERAPY RESEARCH,2009,23(1):116-122.
APA Ji, Deng-Bo,Ye, Jia,Li, Chang-Ling,Wang, Yu-Hwa,Zhao, Jiong,&Cai, Shao-Qing.(2009).Antiaging Effect of Cordyceps sinensis Extract.PHYTOTHERAPY RESEARCH,23(1),116-122.
MLA Ji, Deng-Bo,et al."Antiaging Effect of Cordyceps sinensis Extract".PHYTOTHERAPY RESEARCH 23.1(2009):116-122.
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