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学科主题: 临床医学
题名:
A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates
作者: Qiao, Jie2; Lu, Guangxiu3; Zhang, H. W.4; Chen, Hua5; Ma, Caihong2; Olofsson, Jan I.6; Witjes, Han1; Heijnen, Esther1; Mannaerts, Bernadette1
关键词: GnRH agonist ; GnRH antagonist ; ganirelix ; IVF ; ICSI ; rFSH ; triptorelin
刊名: GYNECOLOGICAL ENDOCRINOLOGY
发表日期: 2012-10-01
DOI: 10.3109/09513590.2012.665103
卷: 28, 期:10, 页:800-804
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Obstetrics & Gynecology
研究领域[WOS]: Endocrinology & Metabolism ; Obstetrics & Gynecology
关键词[WOS]: ASSISTED REPRODUCTIVE TECHNOLOGY ; OVARIAN STIMULATION ; CORIFOLLITROPIN ALPHA ; PROTOCOL ; WOMEN ; IVF ; METAANALYSIS ; HORMONE ; PRETREATMENT ; IVF/ICSI
英文摘要:

Gonadotropin-releasing hormone (GnRH) antagonists for controlled ovarian stimulation (COS) were only recently introduced into China. The efficacy and safety of the GnRH antagonist ganirelix was assessed in a multicenter, controlled, open-label study, in which Chinese women were randomized to either ganirelix (n = 113) or a long GnRH agonist protocol of triptorelin (n = 120). The primary end point was the amount of recombinant follicle-stimulating hormone (rFSH) required to meet the human chorionic gonadotropin criterion (three follicles = 17 mm). The amount of rFSH needed was significantly lower for ganirelix (1272 IU) vs. triptorelin (1416 IU; P < 0.001). Ongoing pregnancy rates per started cycle were 39.8% (ganirelix) and 39.2% (triptorelin). Although both treatments were well tolerated, cancellation due to risk of ovarian hyperstimulation syndrome (OHSS) was less frequent with ganirelix (1.8%) than triptorelin (7.5%) (P = 0.06). Less rFSH was needed in the ganirelix protocol than the long GnRH agonist protocol, with fewer reported cases of OHSS and similar pregnancy rates.

语种: 英语
项目资助者: Merck ; Sharp ; Dohme &amp ; Co. (Whitehouse Station, NJ, USA)
WOS记录号: WOS:000308949200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63206
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.MSD, NL-5340 BH Oss, Netherlands
2.Reprod & Genet Hosp CITIC, Changsha, Hunan, Peoples R China
3.Shanghai Jiai Genet & IVF Inst, Shanghai, Peoples R China
4.MSD Technol, Singapore, Singapore
5.Peking Univ, Reprod Med Ctr, Hosp 3, Beijing 100871, Peoples R China
6.Huazhong Sci & Tech Univ, Tongji Hosp, Wuhan, Peoples R China

Recommended Citation:
Qiao, Jie,Lu, Guangxiu,Zhang, H. W.,et al. A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates[J]. GYNECOLOGICAL ENDOCRINOLOGY,2012,28(10):800-804.
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