北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心  > 期刊论文
学科主题: 临床医学
题名:
A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates
作者: Qiao, Jie2; Lu, Guangxiu3; Zhang, H. W.4; Chen, Hua5; Ma, Caihong2; Olofsson, Jan I.6; Witjes, Han1; Heijnen, Esther1; Mannaerts, Bernadette1
关键词: GnRH agonist ; GnRH antagonist ; ganirelix ; IVF ; ICSI ; rFSH ; triptorelin
刊名: GYNECOLOGICAL ENDOCRINOLOGY
发表日期: 2012-10-01
DOI: 10.3109/09513590.2012.665103
卷: 28, 期:10, 页:800-804
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Obstetrics & Gynecology
研究领域[WOS]: Endocrinology & Metabolism ; Obstetrics & Gynecology
关键词[WOS]: ASSISTED REPRODUCTIVE TECHNOLOGY ; OVARIAN STIMULATION ; CORIFOLLITROPIN ALPHA ; PROTOCOL ; WOMEN ; IVF ; METAANALYSIS ; HORMONE ; PRETREATMENT ; IVF/ICSI
英文摘要:

Gonadotropin-releasing hormone (GnRH) antagonists for controlled ovarian stimulation (COS) were only recently introduced into China. The efficacy and safety of the GnRH antagonist ganirelix was assessed in a multicenter, controlled, open-label study, in which Chinese women were randomized to either ganirelix (n = 113) or a long GnRH agonist protocol of triptorelin (n = 120). The primary end point was the amount of recombinant follicle-stimulating hormone (rFSH) required to meet the human chorionic gonadotropin criterion (three follicles = 17 mm). The amount of rFSH needed was significantly lower for ganirelix (1272 IU) vs. triptorelin (1416 IU; P < 0.001). Ongoing pregnancy rates per started cycle were 39.8% (ganirelix) and 39.2% (triptorelin). Although both treatments were well tolerated, cancellation due to risk of ovarian hyperstimulation syndrome (OHSS) was less frequent with ganirelix (1.8%) than triptorelin (7.5%) (P = 0.06). Less rFSH was needed in the ganirelix protocol than the long GnRH agonist protocol, with fewer reported cases of OHSS and similar pregnancy rates.

语种: 英语
项目资助者: Merck ; Sharp ; Dohme &amp ; Co. (Whitehouse Station, NJ, USA)
WOS记录号: WOS:000308949200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63206
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.MSD, NL-5340 BH Oss, Netherlands
2.Reprod & Genet Hosp CITIC, Changsha, Hunan, Peoples R China
3.Shanghai Jiai Genet & IVF Inst, Shanghai, Peoples R China
4.MSD Technol, Singapore, Singapore
5.Peking Univ, Reprod Med Ctr, Hosp 3, Beijing 100871, Peoples R China
6.Huazhong Sci & Tech Univ, Tongji Hosp, Wuhan, Peoples R China

Recommended Citation:
Qiao, Jie,Lu, Guangxiu,Zhang, H. W.,et al. A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates[J]. GYNECOLOGICAL ENDOCRINOLOGY,2012,28(10):800-804.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Qiao, Jie]'s Articles
[Lu, Guangxiu]'s Articles
[Zhang, H. W.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Qiao, Jie]‘s Articles
[Lu, Guangxiu]‘s Articles
[Zhang, H. W.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace