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A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates
Qiao, Jie2; Lu, Guangxiu3; Zhang, H. W.4; Chen, Hua5; Ma, Caihong2; Olofsson, Jan I.6; Witjes, Han1; Heijnen, Esther1; Mannaerts, Bernadette1
关键词GnRH agonist GnRH antagonist ganirelix IVF ICSI rFSH triptorelin
刊名GYNECOLOGICAL ENDOCRINOLOGY
2012-10-01
DOI10.3109/09513590.2012.665103
28期:10页:800-804
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Obstetrics & Gynecology
资助者Merck ; Sharp ; Dohme &amp ; Co. (Whitehouse Station, NJ, USA) ; Merck ; Sharp ; Dohme &amp ; Co. (Whitehouse Station, NJ, USA)
研究领域[WOS]Endocrinology & Metabolism ; Obstetrics & Gynecology
关键词[WOS]ASSISTED REPRODUCTIVE TECHNOLOGY ; OVARIAN STIMULATION ; CORIFOLLITROPIN ALPHA ; PROTOCOL ; WOMEN ; IVF ; METAANALYSIS ; HORMONE ; PRETREATMENT ; IVF/ICSI
英文摘要

Gonadotropin-releasing hormone (GnRH) antagonists for controlled ovarian stimulation (COS) were only recently introduced into China. The efficacy and safety of the GnRH antagonist ganirelix was assessed in a multicenter, controlled, open-label study, in which Chinese women were randomized to either ganirelix (n = 113) or a long GnRH agonist protocol of triptorelin (n = 120). The primary end point was the amount of recombinant follicle-stimulating hormone (rFSH) required to meet the human chorionic gonadotropin criterion (three follicles = 17 mm). The amount of rFSH needed was significantly lower for ganirelix (1272 IU) vs. triptorelin (1416 IU; P < 0.001). Ongoing pregnancy rates per started cycle were 39.8% (ganirelix) and 39.2% (triptorelin). Although both treatments were well tolerated, cancellation due to risk of ovarian hyperstimulation syndrome (OHSS) was less frequent with ganirelix (1.8%) than triptorelin (7.5%) (P = 0.06). Less rFSH was needed in the ganirelix protocol than the long GnRH agonist protocol, with fewer reported cases of OHSS and similar pregnancy rates.

语种英语
资助者Merck ; Sharp ; Dohme &amp ; Co. (Whitehouse Station, NJ, USA) ; Merck ; Sharp ; Dohme &amp ; Co. (Whitehouse Station, NJ, USA)
WOS记录号WOS:000308949200009
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63206
专题北京大学第三临床医学院_生殖医学中心
作者单位1.MSD, NL-5340 BH Oss, Netherlands
2.Reprod & Genet Hosp CITIC, Changsha, Hunan, Peoples R China
3.Shanghai Jiai Genet & IVF Inst, Shanghai, Peoples R China
4.MSD Technol, Singapore, Singapore
5.Peking Univ, Reprod Med Ctr, Hosp 3, Beijing 100871, Peoples R China
6.Huazhong Sci & Tech Univ, Tongji Hosp, Wuhan, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Jie,Lu, Guangxiu,Zhang, H. W.,et al. A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates[J]. GYNECOLOGICAL ENDOCRINOLOGY,2012,28(10):800-804.
APA Qiao, Jie.,Lu, Guangxiu.,Zhang, H. W..,Chen, Hua.,Ma, Caihong.,...&Mannaerts, Bernadette.(2012).A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates.GYNECOLOGICAL ENDOCRINOLOGY,28(10),800-804.
MLA Qiao, Jie,et al."A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates".GYNECOLOGICAL ENDOCRINOLOGY 28.10(2012):800-804.
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