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Alteration in Chondroitin Sulfate Proteoglycan Expression at the Epicenter of Spinal Cord is Associated with the Loss of Behavioral Function in Tiptoe Walking Yoshimura Mice
Wang, Jun1,2; Wang, Xiaofang3; Rong, Wei2; Lv, Jia1; Wei, Feng1; Liu, Zhongjun1
关键词Tiptoe walking Yoshimura mice CSPG Hyaluronan Astrocyte
刊名NEUROCHEMICAL RESEARCH
2014-12-01
DOI10.1007/s11064-014-1442-8
39期:12页:2394-2406
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]CHRONIC MECHANICAL COMPRESSION ; CERVICAL SPONDYLOTIC MYELOPATHY ; DESTRUCTIVE PATHOLOGICAL-CHANGES ; POSTERIOR LONGITUDINAL LIGAMENT ; EXTRACELLULAR-MATRIX ; SCAR FORMATION ; MOUSE MODEL ; INJURY ; HYALURONAN ; OSSIFICATION
英文摘要

The objective of this study was to explore the correlation between the alteration in chondroitin sulfate proteoglycan (CSPG) expression at the epicenter of spinal cord and the loss of behavioral function in tiptoe walking Yoshimura mice. The tiptoe walking Yoshimura mice (twy) and Institute of Cancer Research (ICR) mice, aged 20 and 26 weeks, were used in the present study. The behavior assessment, micro-computed tomography and immunofluorescent staining were performed. The compressed spinal cord was histologically analyzed. The results showed that the expression of CSPG was statistically higher at the compressed spinal cord for twy mice compared with that at the normal spinal cord for ICR mice. At the 26th week, a large ossification block at the posterior longitudinal ligament of C1-3 was obviously observed at the micro-CT image We observed the BMS Score was significantly correlated with the expression of glial fibrillary acidic protein, CSPG and hyaluronan (P < 0.05). These findings suggest that compression injury induces the higher CSPG expression at the compressed spinal cord in the twy mice. Furthermore, the alteration in CSPG expression at the epicenter of spinal cord is associated with the loss of behavioral function in twy mice.

语种英语
所属项目编号81071522
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000345645700013
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63208
专题北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China
2.Tsinghua Univ, Med Ctr, Beijing 100084, Peoples R China
3.Capital Med Univ, Dept Pharm, Beijing Shijitan Hosp, Beijing 100038, Peoples R China
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GB/T 7714
Wang, Jun,Wang, Xiaofang,Rong, Wei,et al. Alteration in Chondroitin Sulfate Proteoglycan Expression at the Epicenter of Spinal Cord is Associated with the Loss of Behavioral Function in Tiptoe Walking Yoshimura Mice[J]. NEUROCHEMICAL RESEARCH,2014,39(12):2394-2406.
APA Wang, Jun,Wang, Xiaofang,Rong, Wei,Lv, Jia,Wei, Feng,&Liu, Zhongjun.(2014).Alteration in Chondroitin Sulfate Proteoglycan Expression at the Epicenter of Spinal Cord is Associated with the Loss of Behavioral Function in Tiptoe Walking Yoshimura Mice.NEUROCHEMICAL RESEARCH,39(12),2394-2406.
MLA Wang, Jun,et al."Alteration in Chondroitin Sulfate Proteoglycan Expression at the Epicenter of Spinal Cord is Associated with the Loss of Behavioral Function in Tiptoe Walking Yoshimura Mice".NEUROCHEMICAL RESEARCH 39.12(2014):2394-2406.
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