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学科主题: 临床医学
题名:
Alteration in Chondroitin Sulfate Proteoglycan Expression at the Epicenter of Spinal Cord is Associated with the Loss of Behavioral Function in Tiptoe Walking Yoshimura Mice
作者: Wang, Jun1,2; Wang, Xiaofang3; Rong, Wei2; Lv, Jia1; Wei, Feng1; Liu, Zhongjun1
关键词: Tiptoe walking Yoshimura mice ; CSPG ; Hyaluronan ; Astrocyte
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2014-12-01
DOI: 10.1007/s11064-014-1442-8
卷: 39, 期:12, 页:2394-2406
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: CHRONIC MECHANICAL COMPRESSION ; CERVICAL SPONDYLOTIC MYELOPATHY ; DESTRUCTIVE PATHOLOGICAL-CHANGES ; POSTERIOR LONGITUDINAL LIGAMENT ; EXTRACELLULAR-MATRIX ; SCAR FORMATION ; MOUSE MODEL ; INJURY ; HYALURONAN ; OSSIFICATION
英文摘要:

The objective of this study was to explore the correlation between the alteration in chondroitin sulfate proteoglycan (CSPG) expression at the epicenter of spinal cord and the loss of behavioral function in tiptoe walking Yoshimura mice. The tiptoe walking Yoshimura mice (twy) and Institute of Cancer Research (ICR) mice, aged 20 and 26 weeks, were used in the present study. The behavior assessment, micro-computed tomography and immunofluorescent staining were performed. The compressed spinal cord was histologically analyzed. The results showed that the expression of CSPG was statistically higher at the compressed spinal cord for twy mice compared with that at the normal spinal cord for ICR mice. At the 26th week, a large ossification block at the posterior longitudinal ligament of C1-3 was obviously observed at the micro-CT image We observed the BMS Score was significantly correlated with the expression of glial fibrillary acidic protein, CSPG and hyaluronan (P < 0.05). These findings suggest that compression injury induces the higher CSPG expression at the compressed spinal cord in the twy mice. Furthermore, the alteration in CSPG expression at the epicenter of spinal cord is associated with the loss of behavioral function in twy mice.

语种: 英语
所属项目编号: 81071522
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000345645700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63208
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China
2.Tsinghua Univ, Med Ctr, Beijing 100084, Peoples R China
3.Capital Med Univ, Dept Pharm, Beijing Shijitan Hosp, Beijing 100038, Peoples R China

Recommended Citation:
Wang, Jun,Wang, Xiaofang,Rong, Wei,et al. Alteration in Chondroitin Sulfate Proteoglycan Expression at the Epicenter of Spinal Cord is Associated with the Loss of Behavioral Function in Tiptoe Walking Yoshimura Mice[J]. NEUROCHEMICAL RESEARCH,2014,39(12):2394-2406.
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