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学科主题: 临床医学
题名:
Plasma Soluble Urokinase Receptor Level Is Correlated with Podocytes Damage in Patients with IgA Nephropathy
作者: Zhao, Yanfeng1,2,3,4; Liu, Lijun1,2,3,4; Huang, Jing1,2,3,4; Shi, Sufang1,2,3,4; Lv, Jicheng1,2,3,4; Liu, Gang1,2,3,4; Zhao, Minghui1,2,3,4; Zhang, Hong1,2,3,4
刊名: PLOS ONE
发表日期: 2015-07-13
DOI: 10.1371/journal.pone.0132869
卷: 10, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: FOCAL-SEGMENTAL GLOMERULOSCLEROSIS ; OXFORD CLASSIFICATION ; GLOMERULAR-FILTRATION ; DISEASE ; SUPAR ; GLOMERULONEPHRITIS ; VALIDATION ; PREDICTORS ; EXPRESSION ; UPAR
英文摘要:

Background

Focal segmental glomerulosclerosis (FSGS) lesions are similar in characteristics to S lesions of the Oxford classification of IgA nephropathy (IgAN) and may predict poor prognosis. In the present study, we aimed to explore the association between plasma soluble urokinase receptor (suPAR) levels and S lesions and podocytes damage in IgAN patients.

Methods

We enrolled 569 IgAN patients with follow-up data and detected plasma suPAR levels at renal biopsy by enzyme-linked immunosorbent assay.

Results

Plasma suPAR levels in IgAN patients with or without S lesions did not differ significantly (P = 0.411). However, suPAR levels were positively correlated with proteinuria (r = 0.202, P < 0.001), and negatively correlated with estimated glomerular filtration rate (eGFR, r = -0.236, P < 0.001). In the partial correlation to adjust for eGFR, plasma suPAR levels remained positively correlated with proteinuria (r = 0.112, P = 0.023). In a Cox proportional hazards model, higher levels of plasma suPAR were not associated with poor renal outcome. Plasma suPAR levels of IgAN and primary FSGS patients with nephrotic syndrome were not significantly different (P = 0.306). Plasma suPAR levels in patients with extensive effacement of the epithelial cell foot processes of glomerular podocytes were significantly higher than those with segmental effacement on the basis of comparable eGFR (P = 0.036).

Conclusions

In IgAN patients, plasma suPAR levels were not associated with S lesions. However, they were positively associated with proteinuria and negatively associated with eGFR. In addition, plasma suPAR levels were positively associated with the effacement degree of the foot processes, which might partially contribute to the development of proteinuria in patients with IgAN.

语种: 英语
所属项目编号: 81100503 ; 81370809 ; 81021004
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000358193100090
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63209
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Yanfeng,Liu, Lijun,Huang, Jing,et al. Plasma Soluble Urokinase Receptor Level Is Correlated with Podocytes Damage in Patients with IgA Nephropathy[J]. PLOS ONE,2015,10(7).
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