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学科主题临床医学
Plasma Soluble Urokinase Receptor Level Is Correlated with Podocytes Damage in Patients with IgA Nephropathy
Zhao, Yanfeng1,2,3,4; Liu, Lijun1,2,3,4; Huang, Jing1,2,3,4; Shi, Sufang1,2,3,4; Lv, Jicheng1,2,3,4; Liu, Gang1,2,3,4; Zhao, Minghui1,2,3,4; Zhang, Hong1,2,3,4
刊名PLOS ONE
2015-07-13
DOI10.1371/journal.pone.0132869
10期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]FOCAL-SEGMENTAL GLOMERULOSCLEROSIS ; OXFORD CLASSIFICATION ; GLOMERULAR-FILTRATION ; DISEASE ; SUPAR ; GLOMERULONEPHRITIS ; VALIDATION ; PREDICTORS ; EXPRESSION ; UPAR
英文摘要

Background

Focal segmental glomerulosclerosis (FSGS) lesions are similar in characteristics to S lesions of the Oxford classification of IgA nephropathy (IgAN) and may predict poor prognosis. In the present study, we aimed to explore the association between plasma soluble urokinase receptor (suPAR) levels and S lesions and podocytes damage in IgAN patients.

Methods

We enrolled 569 IgAN patients with follow-up data and detected plasma suPAR levels at renal biopsy by enzyme-linked immunosorbent assay.

Results

Plasma suPAR levels in IgAN patients with or without S lesions did not differ significantly (P = 0.411). However, suPAR levels were positively correlated with proteinuria (r = 0.202, P < 0.001), and negatively correlated with estimated glomerular filtration rate (eGFR, r = -0.236, P < 0.001). In the partial correlation to adjust for eGFR, plasma suPAR levels remained positively correlated with proteinuria (r = 0.112, P = 0.023). In a Cox proportional hazards model, higher levels of plasma suPAR were not associated with poor renal outcome. Plasma suPAR levels of IgAN and primary FSGS patients with nephrotic syndrome were not significantly different (P = 0.306). Plasma suPAR levels in patients with extensive effacement of the epithelial cell foot processes of glomerular podocytes were significantly higher than those with segmental effacement on the basis of comparable eGFR (P = 0.036).

Conclusions

In IgAN patients, plasma suPAR levels were not associated with S lesions. However, they were positively associated with proteinuria and negatively associated with eGFR. In addition, plasma suPAR levels were positively associated with the effacement degree of the foot processes, which might partially contribute to the development of proteinuria in patients with IgAN.

语种英语
所属项目编号81100503 ; 81370809 ; 81021004
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000358193100090
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63209
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Yanfeng,Liu, Lijun,Huang, Jing,et al. Plasma Soluble Urokinase Receptor Level Is Correlated with Podocytes Damage in Patients with IgA Nephropathy[J]. PLOS ONE,2015,10(7).
APA Zhao, Yanfeng.,Liu, Lijun.,Huang, Jing.,Shi, Sufang.,Lv, Jicheng.,...&Zhang, Hong.(2015).Plasma Soluble Urokinase Receptor Level Is Correlated with Podocytes Damage in Patients with IgA Nephropathy.PLOS ONE,10(7).
MLA Zhao, Yanfeng,et al."Plasma Soluble Urokinase Receptor Level Is Correlated with Podocytes Damage in Patients with IgA Nephropathy".PLOS ONE 10.7(2015).
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