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学科主题: 临床医学
题名:
Haploidentical hematopoietic stem cell transplantation in adults with Philadelphia-negative acute lymphoblastic leukemia: No difference in the high-and low-risk groups
作者: Mo, Xiao-Dong1,2; Xu, Lan-Ping1,2; Zhang, Xiao-Hui1,2; Liu, Dai-Hong1,2; Wang, Yu1,2; Chen, Huan1,2; Yan, Chen-Hua1,2; Chen, Yu-Hong1,2; Han, Wei1,2; Wang, Feng-Rong1,2; Wang, Jing-Zhi1,2; Liu, Kai-Yan1,2; Huang, Xiao-Jun1,2,3
关键词: Philadelphia-negative acute lymphoblastic leukemia ; adult ; hematopoietic stem cell transplantation ; haploidentical
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2015-04-01
DOI: 10.1002/ijc.29146
卷: 136, 期:7, 页:1697-1707
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; 1ST COMPLETE REMISSION ; MATCHED RELATED DONOR ; ABO INCOMPATIBILITY ; HEMATOLOGIC MALIGNANCIES ; POSTREMISSION THERAPY ; COMORBIDITY INDEX ; UNRELATED DONOR
英文摘要:

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective post-consolidation therapy and curative option for adult patients with Philadelphia chromosome-negative (Ph-negative) acute lymphoblastic leukemia (ALL) in first complete remission (CR1). A human leukocyte antigen (HLA)-haploidentical related donor (haplo-RD) is one of the most important alternative sources for those without HLA-identical sibling donor (ISD). The present study aimed to evaluate the outcomes of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in adult Ph-negative ALL CR1 patients (n=183). We produced an unmanipulated haplo-HSCT protocol including granulocyte colony stimulating factor (G-CSF) for all donors, intensive immune suppression, anti-thymocyte globulin, and combination of G-CSF-primed bone marrow harvest and G-CSF-mobilized peripheral blood stem cells harvest as the source of stem cell grafts. The median age for high-risk versus low-risk groups were 29 versus 23 years. Three-year incidences of relapse mortality and nonrelapse mortality for high-risk versus low-risk groups were 7.1% versus 11.1% (p=0.498) and 18.0% versus 16.2% (p=0.717), respectively. Three-year probabilities of disease-free survival and overall survival for high-risk versus low-risk groups were 67.6% versus 68.2% (p=0.896) and 74.9% versus 72.7% (p=0.981), respectively. Multivariate analysis showed that limited cGVHD and a lower pre-HSCT comorbidity burden were associated with better outcomes. In summary, comparable outcomes were observed among high- and low-risk Ph-negative ALL CR1 patients after haplo-HSCT. Haplo-RD could be considered for adults with Ph-negative ALL in CR1 as an important alternative source of donors in cases when no ISD is available.

What′s new? Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective post-consolidation therapy for adult patients with Philadelphia chromosome-negative (Ph-negative) acute lymphoblastic leukemia (ALL) in first complete remission (CR1). A human leukocyte antigen (HLA)-haploidentical related donor (haplo-RD) is an important alternative source for those without HLA-identical sibling donor (ISD). Here, comparable outcomes were observed among high- and low-risk Ph-negative ALL CR1 patients after haplo-HSCT, and haplo-HSCT might overcome the poor prognostic significance of a high-risk status of Ph-negative ALL CR1 at diagnosis. Haplo-RDs may thus be considered for Ph-negative ALL adult patients in CR1 as an important alternative source of donors.

语种: 英语
所属项目编号: Z111107067311070 ; 81230013
项目资助者: Beijing Municipal Science and Technology Program ; National Natural Science Foundation of China
WOS记录号: WOS:000348443400024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63210
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

Recommended Citation:
Mo, Xiao-Dong,Xu, Lan-Ping,Zhang, Xiao-Hui,et al. Haploidentical hematopoietic stem cell transplantation in adults with Philadelphia-negative acute lymphoblastic leukemia: No difference in the high-and low-risk groups[J]. INTERNATIONAL JOURNAL OF CANCER,2015,136(7):1697-1707.
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