|Folic Acid Use and Nonsyndromic Orofacial Clefts in China A Prospective Cohort Study|
|Li, Song2; Chao, Ann1; Li, Zhu3; Moore, Cynthia A.1; Liu, Yinghui3; Zhu, Jianghui3; Erickson, J. David1; Hao, Ling3; Berry, Robert J.1|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||NEURAL-TUBE DEFECTS ; LIFE-STYLE FACTORS ; ORAL CLEFTS ; BIRTH-DEFECTS ; MULTIVITAMIN SUPPLEMENTATION ; HIGH-PREVALENCE ; NORTHERN CHINA ; FOLATE STATUS ; RISK ; PREVENTION|
Background: Questions remain about the effectiveness, dose, and timing of folic acid in preventing orofacial clefts. Case-control studies report conflicting results. There have been no cohort studies of orofacial clefts and the use of folic acid without other vitamins.
Methods: In a prospective cohort of 240,244 women enrolled between 1993 and 1995 in 1 northern and 2 southern provinces in China, we examined the risk of nonsyndromic cleft lip with or without cleft palate (CL/P) and cleft palate alone (CP) in relation to maternal use of 400 mu g of folic acid without other vitamins.
Results: Daily use of 400 mu g of folic acid without other vitamins, started before the last menstrual period (LMP), was associated with reduced risk of CL/P with adjusted rate ratio (aRR) of 0.69 (95% confidence interval = 0.55-0.87). The greatest reduction in risk was observed in the north among daily users who began taking folic acid pills before LMP (aRR = 0.21 [0.10-0.44]); in the south there was marginal reduction in risk (aRR = 0.81 [0.63-1.05]). No evidence of reduced CL/P risk was observed among women who started folic acid pills on or after their LMP. No persuasive evidence for reduction in CP risk was seen with folic acid pill use at any time.
Conclusion: Daily maternal consumption of 400 mu g of folic acid without other vitamins, started before mother′s LMP, was associated with a reduced risk of CL/P in babies born in a high-prevalence region of China.
|项目编号||U11/CCU015586-02 ; U11/CCU015586-02|
|资助机构||U.S. Centers for Disease Control and Prevention ; Peking University|
|作者单位||1.Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Birth Defects & Dev Disabil, Atlanta, GA 30333 USA|
2.Peking Univ, Dept Pediat, Hosp 3, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Natl Ctr Maternal & Infant Hlth, Dept Hlth Care Epidemiol, Beijing 100871, Peoples R China
|Li, Song,Chao, Ann,Li, Zhu,et al. Folic Acid Use and Nonsyndromic Orofacial Clefts in China A Prospective Cohort Study[J]. EPIDEMIOLOGY,2012,23(3):423-432.|
|APA||Li, Song.,Chao, Ann.,Li, Zhu.,Moore, Cynthia A..,Liu, Yinghui.,...&Berry, Robert J..(2012).Folic Acid Use and Nonsyndromic Orofacial Clefts in China A Prospective Cohort Study.EPIDEMIOLOGY,23(3),423-432.|
|MLA||Li, Song,et al."Folic Acid Use and Nonsyndromic Orofacial Clefts in China A Prospective Cohort Study".EPIDEMIOLOGY 23.3(2012):423-432.|