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学科主题: 临床医学
题名:
Susceptibility of Helicobacter pylori to antibiotics in Chinese patients
作者: Bai, Peng1; Zhou, Li Ya1; Xiao, Xiu Mei2; Luo, Yang1; Ding, Yu1
关键词: antibiotic resistance ; susceptibility ; clarithromycin ; Helicobacter pylori ; metronidazole ; moxifloxacin
刊名: JOURNAL OF DIGESTIVE DISEASES
发表日期: 2015-08-01
DOI: 10.1111/1751-2980.12271
卷: 16, 期:8, 页:464-470
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: TRIPLE THERAPY ; ANTIMICROBIAL RESISTANCE ; ERADICATION THERAPY ; INFECTION ; LEVOFLOXACIN ; METAANALYSIS ; AMOXICILLIN ; MUTATIONS ; TRIAL ; JAPAN
英文摘要:

ObjectiveAntibiotic resistance to Helicobacter pylori (H. pylori) has been increasing worldwide. The study aimed to evaluate in vitro susceptibility and resistance patterns to antibiotics in empirical H. pylori eradication regimens, and to determine the optimal antibiotics for treatment.

MethodsH. pylori strains (n =181) were obtained from gastric biopsies of patients with upper gastrointestinal symptoms who underwent esophagogastroduodenoscopy from March to December 2013. The susceptibility of H. pylori strains to amoxicillin (AMX), metronidazole (MTZ), clarithromycin (CLR), amoxicillin-clavulanate (AMC), cephalothin (CEP), cefuroxime (CXM), cefixime (CFM), moxifloxacin (MFX) and minocycline (MNO) was determined.

ResultsDual resistance to MTZ+CLR was detected in 48 (26.5%) isolates, MTZ+MFX in 94 (51.9%), and CLR+MFX in 49 (27.1%). Overall, 41 (22.7%) were resistant to MTZ+CLR+MFX. MTZ and CLR resistance rates were significantly associated with the history of H. pylori eradication but there was no significant difference in MFX resistance rates between treated and untreated patients (P=0.674). No significant relationship was found between antibiotic resistance and patient′s gender, age, endoscopic findings, inflammatory severity or gastric atrophy.

ConclusionsAMX, AMC, MNO and cephalosporins, but not MTZ, CLR and MFX, showed good in vitro anti-H. pylori activity. Among cephalosporins, CXM was the most active. H. pylori resistance is higher in patients with previous H. pylori eradication.

语种: 英语
所属项目编号: 2012BAI06B02
项目资助者: National Science Technology Pillar Program in the Twelfth Five-Year Plan Period, China
WOS记录号: WOS:000361182500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63215
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China

Recommended Citation:
Bai, Peng,Zhou, Li Ya,Xiao, Xiu Mei,et al. Susceptibility of Helicobacter pylori to antibiotics in Chinese patients[J]. JOURNAL OF DIGESTIVE DISEASES,2015,16(8):464-470.
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