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学科主题临床医学
Susceptibility of Helicobacter pylori to antibiotics in Chinese patients
Bai, Peng1; Zhou, Li Ya1; Xiao, Xiu Mei2; Luo, Yang1; Ding, Yu1
关键词antibiotic resistance susceptibility clarithromycin Helicobacter pylori metronidazole moxifloxacin
刊名JOURNAL OF DIGESTIVE DISEASES
2015-08-01
DOI10.1111/1751-2980.12271
16期:8页:464-470
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]TRIPLE THERAPY ; ANTIMICROBIAL RESISTANCE ; ERADICATION THERAPY ; INFECTION ; LEVOFLOXACIN ; METAANALYSIS ; AMOXICILLIN ; MUTATIONS ; TRIAL ; JAPAN
英文摘要

ObjectiveAntibiotic resistance to Helicobacter pylori (H. pylori) has been increasing worldwide. The study aimed to evaluate in vitro susceptibility and resistance patterns to antibiotics in empirical H. pylori eradication regimens, and to determine the optimal antibiotics for treatment.

MethodsH. pylori strains (n =181) were obtained from gastric biopsies of patients with upper gastrointestinal symptoms who underwent esophagogastroduodenoscopy from March to December 2013. The susceptibility of H. pylori strains to amoxicillin (AMX), metronidazole (MTZ), clarithromycin (CLR), amoxicillin-clavulanate (AMC), cephalothin (CEP), cefuroxime (CXM), cefixime (CFM), moxifloxacin (MFX) and minocycline (MNO) was determined.

ResultsDual resistance to MTZ+CLR was detected in 48 (26.5%) isolates, MTZ+MFX in 94 (51.9%), and CLR+MFX in 49 (27.1%). Overall, 41 (22.7%) were resistant to MTZ+CLR+MFX. MTZ and CLR resistance rates were significantly associated with the history of H. pylori eradication but there was no significant difference in MFX resistance rates between treated and untreated patients (P=0.674). No significant relationship was found between antibiotic resistance and patient′s gender, age, endoscopic findings, inflammatory severity or gastric atrophy.

ConclusionsAMX, AMC, MNO and cephalosporins, but not MTZ, CLR and MFX, showed good in vitro anti-H. pylori activity. Among cephalosporins, CXM was the most active. H. pylori resistance is higher in patients with previous H. pylori eradication.

语种英语
WOS记录号WOS:000361182500006
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63215
专题北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Bai, Peng,Zhou, Li Ya,Xiao, Xiu Mei,et al. Susceptibility of Helicobacter pylori to antibiotics in Chinese patients[J]. JOURNAL OF DIGESTIVE DISEASES,2015,16(8):464-470.
APA Bai, Peng,Zhou, Li Ya,Xiao, Xiu Mei,Luo, Yang,&Ding, Yu.(2015).Susceptibility of Helicobacter pylori to antibiotics in Chinese patients.JOURNAL OF DIGESTIVE DISEASES,16(8),464-470.
MLA Bai, Peng,et al."Susceptibility of Helicobacter pylori to antibiotics in Chinese patients".JOURNAL OF DIGESTIVE DISEASES 16.8(2015):464-470.
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