IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients
Liu, Bao-Ming1; Li, Tong1; Xu, Jie2; Li, Xiao-Guang2; Dong, Jian-Ping3; Yan, Ping3; Yang, Jing-Xian1; Yan, Ling1; Gao, Zhi-Yong4; Li, Wen-Peng1; Sun, Xie-Wen5; Wang, Yu-Hua5; Jiao, Xiu-Juan5; Hou, Chun-Sheng6; Zhuang, Hui1
关键词Hepatitis B virus Resistance Mutation Nucleos(t)ide analogue naive Genotype Polymorphic
刊名ANTIVIRAL RESEARCH
2010-03-01
DOI10.1016/j.antiviral.2009.12.006
85期:3页:512-519
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Virology
研究领域[WOS]Pharmacology & Pharmacy ; Virology
关键词[WOS]HBV DRUG-RESISTANCE ; ADEFOVIR DIPIVOXIL ; FAMCICLOVIR RESISTANCE ; REPLICATION CAPACITY ; LAMIVUDINE THERAPY ; POLYMERASE GENES ; ESCAPE MUTANTS ; YMDD MOTIF ; IN-VITRO ; PREVALENCE
英文摘要

Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and sequenced among 192 nucleos(t)ide analogue (NA)-naive Chinese patients with chronic hepatitis B. Deduced amino acids (AAs) at 42 previously reported potential NA resistance (NAr) mutation positions in RT region were analyzed. Patients were found with either B-genotype (28.65%) or C-genotype (71.35%) infections. Rt53, rt91, rt124, rt134, rt:221, rt224, rt238 and rt256 were identified as B- and C-genotype-dependent polymorphic AA positions. AA substitutions at 11 classical NAr mutation positions, i.e. rt80, rt169, rt173, rt180, rt181, rt184, rt194, rt202, rt204, rt236 and rt250, were not detected. However, potential NAr mutations were found in 30.73% (59/192) isolates, which involved 18 positions including rt53, rt:207, rt229, rt238 and rt256, etc. The concomitant AA changes of HBsAg occurred in 16.67% (32/192) isolates including sG145R mutation. One-third of mutation positions were located in functional RT domains(e.g. rt207 and rt233), A-B interdomains (overlapping HBsAg ′a′ determinant and showing most concomitant immune-associated mutations)and non-A-B interdomains (e.g. rt191 and rt213), respectively. Genotypes B and C each showed several preferred positions to mutate. These results might provide insights into understanding the evolution and selection basis of NAr HBV strains under antiviral therapy. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000275807800009
项目编号2005CB523104 ; 2008ZX10002-004 ; 2009ZX10004-314
资助机构Chinese National Key Basic Research Project ; Major Science and Technology Special Project of China Eleventh Five-year Plan
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被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63216
专题北京大学基础医学院_病原生物学系
作者单位1.Beijing Municipal Ctr Dis Prevent & Control, Beijing, Peoples R China
2.Qinhuangdao Third Hosp, Dept Infect Dis, Qinhuangdao, Peoples R China
3.Beijing Haidian Hosp, Dept Infect Dis, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
5.Peking Univ, Hosp 3, Dept Infect Dis, Beijing 100871, Peoples R China
6.Shandong Jining Infect Dis Hosp, Dept Infect Dis, Jining, Peoples R China
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Liu, Bao-Ming,Li, Tong,Xu, Jie,et al. Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients[J]. ANTIVIRAL RESEARCH,2010,85(3):512-519.
APA Liu, Bao-Ming.,Li, Tong.,Xu, Jie.,Li, Xiao-Guang.,Dong, Jian-Ping.,...&Zhuang, Hui.(2010).Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients.ANTIVIRAL RESEARCH,85(3),512-519.
MLA Liu, Bao-Ming,et al."Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients".ANTIVIRAL RESEARCH 85.3(2010):512-519.
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