北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients
作者: Liu, Bao-Ming1; Li, Tong1; Xu, Jie2; Li, Xiao-Guang2; Dong, Jian-Ping3; Yan, Ping3; Yang, Jing-Xian1; Yan, Ling1; Gao, Zhi-Yong4; Li, Wen-Peng1; Sun, Xie-Wen5; Wang, Yu-Hua5; Jiao, Xiu-Juan5; Hou, Chun-Sheng6; Zhuang, Hui1
关键词: Hepatitis B virus ; Resistance ; Mutation ; Nucleos(t)ide analogue naive ; Genotype ; Polymorphic
刊名: ANTIVIRAL RESEARCH
发表日期: 2010-03-01
DOI: 10.1016/j.antiviral.2009.12.006
卷: 85, 期:3, 页:512-519
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Virology
研究领域[WOS]: Pharmacology & Pharmacy ; Virology
关键词[WOS]: HBV DRUG-RESISTANCE ; ADEFOVIR DIPIVOXIL ; FAMCICLOVIR RESISTANCE ; REPLICATION CAPACITY ; LAMIVUDINE THERAPY ; POLYMERASE GENES ; ESCAPE MUTANTS ; YMDD MOTIF ; IN-VITRO ; PREVALENCE
英文摘要:

Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and sequenced among 192 nucleos(t)ide analogue (NA)-naive Chinese patients with chronic hepatitis B. Deduced amino acids (AAs) at 42 previously reported potential NA resistance (NAr) mutation positions in RT region were analyzed. Patients were found with either B-genotype (28.65%) or C-genotype (71.35%) infections. Rt53, rt91, rt124, rt134, rt:221, rt224, rt238 and rt256 were identified as B- and C-genotype-dependent polymorphic AA positions. AA substitutions at 11 classical NAr mutation positions, i.e. rt80, rt169, rt173, rt180, rt181, rt184, rt194, rt202, rt204, rt236 and rt250, were not detected. However, potential NAr mutations were found in 30.73% (59/192) isolates, which involved 18 positions including rt53, rt:207, rt229, rt238 and rt256, etc. The concomitant AA changes of HBsAg occurred in 16.67% (32/192) isolates including sG145R mutation. One-third of mutation positions were located in functional RT domains(e.g. rt207 and rt233), A-B interdomains (overlapping HBsAg ′a′ determinant and showing most concomitant immune-associated mutations)and non-A-B interdomains (e.g. rt191 and rt213), respectively. Genotypes B and C each showed several preferred positions to mutate. These results might provide insights into understanding the evolution and selection basis of NAr HBV strains under antiviral therapy. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2005CB523104 ; 2008ZX10002-004 ; 2009ZX10004-314
项目资助者: Chinese National Key Basic Research Project ; Major Science and Technology Special Project of China Eleventh Five-year Plan
WOS记录号: WOS:000275807800009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63216
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients.pdf(482KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Beijing Municipal Ctr Dis Prevent & Control, Beijing, Peoples R China
2.Qinhuangdao Third Hosp, Dept Infect Dis, Qinhuangdao, Peoples R China
3.Beijing Haidian Hosp, Dept Infect Dis, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
5.Peking Univ, Hosp 3, Dept Infect Dis, Beijing 100871, Peoples R China
6.Shandong Jining Infect Dis Hosp, Dept Infect Dis, Jining, Peoples R China

Recommended Citation:
Liu, Bao-Ming,Li, Tong,Xu, Jie,et al. Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients[J]. ANTIVIRAL RESEARCH,2010,85(3):512-519.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Bao-Ming]'s Articles
[Li, Tong]'s Articles
[Xu, Jie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Bao-Ming]‘s Articles
[Li, Tong]‘s Articles
[Xu, Jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace