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学科主题: 精神卫生
题名:
Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population
作者: Zhang, Xiang Yang; Tan, Yun Long; Zhou, Dong Feng; Haile, Colin N.; Cao, Lian Yuan; Xu, Qi; Shen, Yan; Kosten, Therese A.; Kosten, Thomas R.
刊名: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
发表日期: 2007-06-01
DOI: 10.1097/jcp.0b013e3180582412
卷: 27, 期:3, 页:246-251
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: 5-HT2C RECEPTOR GENE ; ANTIPSYCHOTIC-DRUGS ; ATYPICAL ANTIPSYCHOTICS ; BODY-WEIGHT ; OBESE GENE ; SERUM LEPTIN ; PHARMACOGENETICS ; OLANZAPINE ; PROTEIN ; DEFICIENCY
英文摘要:

Weight gain is a problem commonly encountered with antipsychotic treatment and has become more apparent with increasing use of the newer atypical antipsychotics. The adipocyte-derived hormone, leptin, has been associated with body weight and energy homeostasis, and abnormal regulation of leptin could play a role in weight gain induced by antipsychotics. We investigated whether a leptin gene promoter variant affected weight gain after long-term treatment with clozapine in chronic schizophrenia. Leptin G2548A polymorphism was genotyped in 102 Chinese Han inpatients with chronic schizophrenia treated with clozapine. Weight gains, expressed as change in body mass index (BMI), were monitored after long-term clozapine treatment. We found a significant relationship between the 3 leptin G/A genotypes and mean BMI gain (F-2,(99) = 3.35, P = 0.039, r(2) = 0.09). Moreover, genotype had a strong effect on BMI gain in male (P = 0.004, r(2) = 0.16), but not in female patients (P > 0.05). Thus, variation in the leptin gene may be a risk factor for weight gain in male patients with schizophrenia on long-term clozapine treatment.

语种: 英语
WOS记录号: WOS:000246711000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63224
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Beijing Hui Iong Guan Hosp, Beijing, Peoples R China
3.Baylor Coll Med, Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77039 USA
4.Chinese Acad Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Beijing, Peoples R China
5.Peking Union Med Coll, Beijing, Peoples R China

Recommended Citation:
Zhang, Xiang Yang,Tan, Yun Long,Zhou, Dong Feng,et al. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2007,27(3):246-251.
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