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Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population
Zhang, Xiang Yang; Tan, Yun Long; Zhou, Dong Feng; Haile, Colin N.; Cao, Lian Yuan; Xu, Qi; Shen, Yan; Kosten, Therese A.; Kosten, Thomas R.
刊名JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
2007-06-01
DOI10.1097/jcp.0b013e3180582412
27期:3页:246-251
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]5-HT2C RECEPTOR GENE ; ANTIPSYCHOTIC-DRUGS ; ATYPICAL ANTIPSYCHOTICS ; BODY-WEIGHT ; OBESE GENE ; SERUM LEPTIN ; PHARMACOGENETICS ; OLANZAPINE ; PROTEIN ; DEFICIENCY
英文摘要

Weight gain is a problem commonly encountered with antipsychotic treatment and has become more apparent with increasing use of the newer atypical antipsychotics. The adipocyte-derived hormone, leptin, has been associated with body weight and energy homeostasis, and abnormal regulation of leptin could play a role in weight gain induced by antipsychotics. We investigated whether a leptin gene promoter variant affected weight gain after long-term treatment with clozapine in chronic schizophrenia. Leptin G2548A polymorphism was genotyped in 102 Chinese Han inpatients with chronic schizophrenia treated with clozapine. Weight gains, expressed as change in body mass index (BMI), were monitored after long-term clozapine treatment. We found a significant relationship between the 3 leptin G/A genotypes and mean BMI gain (F-2,(99) = 3.35, P = 0.039, r(2) = 0.09). Moreover, genotype had a strong effect on BMI gain in male (P = 0.004, r(2) = 0.16), but not in female patients (P > 0.05). Thus, variation in the leptin gene may be a risk factor for weight gain in male patients with schizophrenia on long-term clozapine treatment.

语种英语
WOS记录号WOS:000246711000002
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63224
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Beijing Hui Iong Guan Hosp, Beijing, Peoples R China
3.Baylor Coll Med, Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77039 USA
4.Chinese Acad Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Beijing, Peoples R China
5.Peking Union Med Coll, Beijing, Peoples R China
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GB/T 7714
Zhang, Xiang Yang,Tan, Yun Long,Zhou, Dong Feng,et al. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2007,27(3):246-251.
APA Zhang, Xiang Yang.,Tan, Yun Long.,Zhou, Dong Feng.,Haile, Colin N..,Cao, Lian Yuan.,...&Kosten, Thomas R..(2007).Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population.JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,27(3),246-251.
MLA Zhang, Xiang Yang,et al."Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population".JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 27.3(2007):246-251.
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