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Serum lutein and its dynamic changes during supplementation with lutein in Chinese subjects
Ma, Le; Lin, Xiao-Ming; Xu, Xian-Rong; Zou, Zhi-Yong; Wang, Zi-Xin; Huang, Yang-Mu; Li, Ying
关键词lutein beta-carotene carotenoid interactions adults
刊名ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
2009
18期:3页:318-325
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]MACULAR PIGMENT DENSITY ; PERSONS AGED 60 ; BETA-CAROTENE ; OPTICAL-DENSITY ; TISSUE CONCENTRATIONS ; ALPHA-TOCOPHEROL ; VITAMIN-C ; ZEAXANTHIN ; DEGENERATION ; OLDER
英文摘要

Observational epidemiological studies have shown that a high consumption of lutein-containing foods is associated with decreased risk of chronic diseases. However. results are inconsistent, suggesting the possibility that confounders may impact serum lutein concentration after consumption. The present study aimed to determine the factors affecting serum lutein status and to characterize dynamic changes of lutein concentration in serum during lutein supplementation in healthy Chinese subjects. After baseline characteristics were determined, thirty-seven healthy participants were randomized to receive 6 mg lutein/d, 12 mg lutein/d, or placebo for 12 weeks, as well as to be observed for 6 additional weeks after the cessation of supplementation. Serum levels of lutein and beta-carotene were measured by HPLC at weeks 0, 1, 3, 6, 9, 12 and 18. Dietary intake was estimated by food-frequency questionnaires. No significant sex differences were found in serum concentration of lutein. Serum lutein level positively correlated with dietary lutein, retinol equivalents, vitamin C, vitamin E, beta-carotene and fat intake after adjustment for caloric intake, but not with BMI. After 12-weeks of supplementation, lutein levels increased approximately 1.8-fold and 2.3-fold for the 6-, and 12-mg dose groups respectively, approaching a plateau at week 9, and then decreased to baseline values at week 18. No adverse events or reductions in serum beta-carotene were observed throughout the study. Our findings indicate that increasing the consumption of lutein-rich fruit and vegetables can be considered as a long-term, sustainable and safe approach to reach and maintain high serum levels of lutein.

语种英语
WOS记录号WOS:000270836300003
项目编号NSFC-30671758 ; 06094
资助机构National Natural Science Foundation of China ; Chinese Nutrition Society
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63227
专题北京大学公共卫生学院
北京大学公共卫生学院_全球卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ma, Le,Lin, Xiao-Ming,Xu, Xian-Rong,et al. Serum lutein and its dynamic changes during supplementation with lutein in Chinese subjects[J]. ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION,2009,18(3):318-325.
APA Ma, Le.,Lin, Xiao-Ming.,Xu, Xian-Rong.,Zou, Zhi-Yong.,Wang, Zi-Xin.,...&Li, Ying.(2009).Serum lutein and its dynamic changes during supplementation with lutein in Chinese subjects.ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION,18(3),318-325.
MLA Ma, Le,et al."Serum lutein and its dynamic changes during supplementation with lutein in Chinese subjects".ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION 18.3(2009):318-325.
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