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学科主题: 临床医学
题名:
Validation of chronic kidney disease risk categorization system in Chinese patients with kidney disease: A cohort study
作者: Liu, Qingyan1; Lv, Jicheng2,3,4,5; Li, Haixia1; Jiao, Lili1; Yang, Hongyun1; Song, Yinan1; Xu, Guobin1
关键词: chronic kidney disease ; glomerular filtration rate ; prognosis ; proteinuria
刊名: NEPHROLOGY
发表日期: 2015-12-01
DOI: 10.1111/nep.12528
卷: 20, 期:12, 页:936-944
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; STAGE RENAL-DISEASE ; COLLABORATIVE METAANALYSIS ; POPULATION COHORTS ; HIGHER ALBUMINURIA ; GENERAL-POPULATION ; ALL-CAUSE ; MORTALITY ; OUTCOMES ; PROTEINURIA
英文摘要:

AimTo validate the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines risk stratification system based on the combination of estimated glomerular filtration rate (eGFR) and proteinuria.

MethodsThis was a cohort study. A total of 1219 study population were recruited. Estimated GFR and proteinuria measured by using 24 h urine protein excretion rate (PER) were predictors. Adverse outcomes included all-cause mortality (ACM) and end-stage renal disease (ESRD). Follow-up was done by regular visit, telephone interview and electronic medical records.

ResultsOver a median follow-up of 4.6 years, 153 (12.6%) and 43 (3.5%) patients experienced ESRD and ACM, respectively. On multivariable analysis, the adjusted hazard ratio for ESRD and ACM (compared with patients with eGFR>60mL/min per 1.73m(2)) was of 29.8 and 3.6 for those with eGFR of 15-29mL/min per 1.73m(2), respectively. The adjusted hazard ratio for ESRD and ACM (compared with patients with PER<150mg/24h) was of 15.9 and 3.9 for those with PER>500mg/24h. Higher KDIGO guidelines risk categories (indicating lower eGFR or higher proteinuria) were associated with a graded increase in the risk for the ESRD (P<0.001) and ACM (P<0.001). Reclassification of KDIGO guidelines risk categories yielded net reclassification improvements for those with ESRD or ACM event (NRIevents) of 33.3% or 30.2%.

ConclusionLower eGFR and higher proteinuria are risk factors for ESRD and ACM in Chinese patients. The KDIGO guidelines risk categorization system assigned patients who went on to have the event to more appropriate CKD risk categories.

Summary at a Glance This paper provides a validation of the KDIGO risk stratification in a Chinese population living in China, based on a combination of eGFR and proteinuria.

语种: 英语
所属项目编号: 81101308
项目资助者: National Science Foundation of China
WOS记录号: WOS:000364647400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63228
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Div Nephrol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100871, Peoples R China
5.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Qingyan,Lv, Jicheng,Li, Haixia,et al. Validation of chronic kidney disease risk categorization system in Chinese patients with kidney disease: A cohort study[J]. NEPHROLOGY,2015,20(12):936-944.
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