IR@PKUHSC  > 北京大学第一临床医学院
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Validation of chronic kidney disease risk categorization system in Chinese patients with kidney disease: A cohort study
Liu, Qingyan1; Lv, Jicheng2,3,4,5; Li, Haixia1; Jiao, Lili1; Yang, Hongyun1; Song, Yinan1; Xu, Guobin1
关键词chronic kidney disease glomerular filtration rate prognosis proteinuria
刊名NEPHROLOGY
2015-12-01
DOI10.1111/nep.12528
20期:12页:936-944
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GLOMERULAR-FILTRATION-RATE ; STAGE RENAL-DISEASE ; COLLABORATIVE METAANALYSIS ; POPULATION COHORTS ; HIGHER ALBUMINURIA ; GENERAL-POPULATION ; ALL-CAUSE ; MORTALITY ; OUTCOMES ; PROTEINURIA
英文摘要

AimTo validate the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines risk stratification system based on the combination of estimated glomerular filtration rate (eGFR) and proteinuria.

MethodsThis was a cohort study. A total of 1219 study population were recruited. Estimated GFR and proteinuria measured by using 24 h urine protein excretion rate (PER) were predictors. Adverse outcomes included all-cause mortality (ACM) and end-stage renal disease (ESRD). Follow-up was done by regular visit, telephone interview and electronic medical records.

ResultsOver a median follow-up of 4.6 years, 153 (12.6%) and 43 (3.5%) patients experienced ESRD and ACM, respectively. On multivariable analysis, the adjusted hazard ratio for ESRD and ACM (compared with patients with eGFR>60mL/min per 1.73m(2)) was of 29.8 and 3.6 for those with eGFR of 15-29mL/min per 1.73m(2), respectively. The adjusted hazard ratio for ESRD and ACM (compared with patients with PER<150mg/24h) was of 15.9 and 3.9 for those with PER>500mg/24h. Higher KDIGO guidelines risk categories (indicating lower eGFR or higher proteinuria) were associated with a graded increase in the risk for the ESRD (P<0.001) and ACM (P<0.001). Reclassification of KDIGO guidelines risk categories yielded net reclassification improvements for those with ESRD or ACM event (NRIevents) of 33.3% or 30.2%.

ConclusionLower eGFR and higher proteinuria are risk factors for ESRD and ACM in Chinese patients. The KDIGO guidelines risk categorization system assigned patients who went on to have the event to more appropriate CKD risk categories.

Summary at a Glance This paper provides a validation of the KDIGO risk stratification in a Chinese population living in China, based on a combination of eGFR and proteinuria.

语种英语
WOS记录号WOS:000364647400010
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63228
专题北京大学第一临床医学院
北京大学第一临床医学院_检验科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Div Nephrol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100871, Peoples R China
5.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Qingyan,Lv, Jicheng,Li, Haixia,et al. Validation of chronic kidney disease risk categorization system in Chinese patients with kidney disease: A cohort study[J]. NEPHROLOGY,2015,20(12):936-944.
APA Liu, Qingyan.,Lv, Jicheng.,Li, Haixia.,Jiao, Lili.,Yang, Hongyun.,...&Xu, Guobin.(2015).Validation of chronic kidney disease risk categorization system in Chinese patients with kidney disease: A cohort study.NEPHROLOGY,20(12),936-944.
MLA Liu, Qingyan,et al."Validation of chronic kidney disease risk categorization system in Chinese patients with kidney disease: A cohort study".NEPHROLOGY 20.12(2015):936-944.
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