北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
HER2 discordance between paired primary gastric cancer and metastasis: a meta-analysis
作者: Peng, Zhi1; Zou, Jianling1; Zhang, Xiaotian1; Yang, Yehong2,3; Gao, Jing1; Li, Yilin1; Li, Yanyan1; Shen, Lin1
关键词: Gastric cancer (GC) ; human epidermal growth factor receptor 2 (HER2) ; discordance ; meta-analysis
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2015-04-01
DOI: 10.3978/j.issn.1000-9604.2014.12.09
卷: 27, 期:2, 页:163-+
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: FACTOR RECEPTOR 2 ; BREAST-CANCER ; TISSUE MICROARRAY ; EXPRESSION ; CARCINOMA ; AMPLIFICATION ; ERBB2 ; HETEROGENEITY ; PARAMETERS ; DISEASE
英文摘要:

Background: A number of studies have examined human epidermal growth factor receptor 2 (HER2) status in primary gastric cancer (GC) and associated metastasis, some showed their great concordance in HER2 expression, but others demonstrated notable discordance. There is still little consensus on HER2 discordance, therefore, a systematic review and meta-analysis was conducted to assess the status on HER2 discordance between primary GC and its paired metastasis.

Methods: PubMed, EMBASE, ASCO and The Cochrane Library were searched for studies that explored the concordance between primary tumor and metastasis in patients with GC up to 10 March, 2014. Data of discordance of HER2 between primary GC and corresponding metastasis were extracted from the publications and random-effects models were used to estimate pooled discordance proportions.

Results: Eighteen articles including 1,867 patients were included for the meta-analysis in accordance with the selection criteria. Pooled discordance proportions were 7% [95% confidence interval (CI): 5-10%] for HER2 status. Pooled proportions of tumors shifting from positive to negative and from negative to positive were 17% (95% CI: 7-29%) and 4% (95% CI: 2-6%) respectively. No publication bias was found in the meta-analysis.

Conclusions: The discordance of HER2 status is not rare in primary and metastatic GC through our meta-analysis. Prospective studies are needed to testify the clinical significance of the discordance of HER2 status.

语种: 英语
所属项目编号: 81172110 ; 2012AA 02A 504 ; Z11110706730000 ; 7142034 ; 2013M530494
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program ; Beijing Municipal Science &amp ; Technology Commission Program ; Beijing Natural Science Foundation ; China Postdoctoral Science Foundation
WOS记录号: WOS:000354445000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63231
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China
3.Peking Union Med Coll, Sch Basic Med, Beijing 100730, Peoples R China

Recommended Citation:
Peng, Zhi,Zou, Jianling,Zhang, Xiaotian,et al. HER2 discordance between paired primary gastric cancer and metastasis: a meta-analysis[J]. CHINESE JOURNAL OF CANCER RESEARCH,2015,27(2):163-+.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Peng, Zhi]'s Articles
[Zou, Jianling]'s Articles
[Zhang, Xiaotian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Peng, Zhi]‘s Articles
[Zou, Jianling]‘s Articles
[Zhang, Xiaotian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace