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学科主题: 药学
题名:
A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs
作者: Wu, Ren-Min; Qi, Na; Jia, Yu-Wen; Guan, Zhu; Zhang, Liang-Ren; Zhang, Li-He; Yang, Zhen-Jun
关键词: cADPR ; cIDPRE ; Phosphoramidite strategy ; Cyclopyrophosphate
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2014-12-01
DOI: 10.1016/j.cclet.2014.07.010
卷: 25, 期:12, 页:1583-1585
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CYCLIC ADP-RIBOSE ; ADENOSINE-DIPHOSPHORIBOSE CADPR ; RELEASE ACTIVITY ; CALCIUM-RELEASE ; PHARMACOLOGY
英文摘要:

A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE (P-S(1)-cIDPRE) was developed. The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy. (C) 2014 Zhen-Jun Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种: 英语
所属项目编号: 21332010 ; 21172010 ; 21002004
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000348013600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63232
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wu, Ren-Min,Qi, Na,Jia, Yu-Wen,et al. A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs[J]. CHINESE CHEMICAL LETTERS,2014,25(12):1583-1585.
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