A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE (P-S(1)-cIDPRE) was developed. The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy. (C) 2014 Zhen-Jun Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation:
Wu, Ren-Min,Qi, Na,Jia, Yu-Wen,et al. A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs[J]. CHINESE CHEMICAL LETTERS,2014,25(12):1583-1585.
