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学科主题基础医学
Comparative genomic analysis between typhoidal and non-typhoidal Salmonella serovars reveals typhoid-specific protein families
Zou, Qing-Hua1; Li, Ren-Qing2; Liu, Gui-Rong3; Liu, Shu-Lin1,4,5,6
关键词Salmonella S. Typhi S. Paratyphi A S. Paratyphi B S. Paratyphi C Specific protein families
刊名INFECTION GENETICS AND EVOLUTION
2014-08-01
DOI10.1016/j.meegid.2014.06.008
26期:0页:295-302
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]PARATYPHI C ; ENTERICA SEROVARS ; TYPHIMURIUM ; DIVERGENCE ; SEQUENCE ; STRAINS ; GENE ; ELECTROPHORESIS ; COLONIZATION ; CHOLERAESUIS
英文摘要

Background: The genus Salmonella contains more than 2600 serovars. While most cause a self-limiting gastroenteritis, four serovars, S. Typhi, S. Paratyphi A, B and C, elicit typhoid, a potentially fatal systemic infection. Because of the prevalence in certain regions, such as South Asia, and the disease severity of typhoidal Salmonella infections, comprehensive studies are needed to elucidate the pathogenesis of diseases caused by these typhoidal serovars.

Results: We performed comparative genomic analyses on eight human typhoidal strains and 27 non-human typhoidal Salmonella strains to elucidate their evolutionary relationships and identify the genes specific to the four typhoidal serovars. Our results indicate that Salmonella may have an open pangenome. A core-genome based phylogeny demonstrated that divergence between S. Paratyphi A and S. Typhi took place not long ago and S. Paratyphi B shared a recent common ancestor with S. Paratyphi C. Of great interest, the divergence between S. Paratyphi B and S. Paratyphi C was shown to be more recent than that between S. Paratyphi A and S. Typhi. Alignment and comparisons of the genomes identified unique complements of protein families to each of the typhoidal serovars. Most of these protein families are phage related and some are candidate virulence factors. Importantly, we found 88 protein families specific to two to three of the four typhoidal serovars. All but two of the 88 genes are present in S. Typhi, with a few in the three paratyphoidal serovars but none in the non-human typhoidal serovars. Most of these genes are predicted to encode hypothetical proteins and some are known to code for virulence factors such as Vi polysaccharide related proteins.

Conclusions: By comprehensive genomic comparisons, we identified protein families specific to the human typhoidal serovars, which will greatly facilitate investigations on typhoid pathogenesis. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000339954500037
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63234
专题北京大学基础医学院_病原生物学系
作者单位1.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB, Canada
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100871, Peoples R China
3.Beijing Ctr Dis Control & Prevent, Inst Immunol, Beijing, Peoples R China
4.Harbin Med Univ, Genom Res Ctr, State Prov Key Labs Biomed Pharmaceut China, Harbin 150081, Peoples R China
5.Harbin Med Univ, HMU UCFM Ctr Infect & Genom, Harbin 150081, Peoples R China
6.Harbin Med Univ, Dept Biopharmaceut Sci, Fac Pharm, Harbin 150081, Peoples R China
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Zou, Qing-Hua,Li, Ren-Qing,Liu, Gui-Rong,et al. Comparative genomic analysis between typhoidal and non-typhoidal Salmonella serovars reveals typhoid-specific protein families[J]. INFECTION GENETICS AND EVOLUTION,2014,26(0):295-302.
APA Zou, Qing-Hua,Li, Ren-Qing,Liu, Gui-Rong,&Liu, Shu-Lin.(2014).Comparative genomic analysis between typhoidal and non-typhoidal Salmonella serovars reveals typhoid-specific protein families.INFECTION GENETICS AND EVOLUTION,26(0),295-302.
MLA Zou, Qing-Hua,et al."Comparative genomic analysis between typhoidal and non-typhoidal Salmonella serovars reveals typhoid-specific protein families".INFECTION GENETICS AND EVOLUTION 26.0(2014):295-302.
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