北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
Comparative genomic analysis between typhoidal and non-typhoidal Salmonella serovars reveals typhoid-specific protein families
作者: Zou, Qing-Hua1; Li, Ren-Qing2; Liu, Gui-Rong3; Liu, Shu-Lin1,4,5,6
关键词: Salmonella ; S. Typhi ; S. Paratyphi A ; S. Paratyphi B ; S. Paratyphi C ; Specific protein families
刊名: INFECTION GENETICS AND EVOLUTION
发表日期: 2014-08-01
DOI: 10.1016/j.meegid.2014.06.008
卷: 26, 期:0, 页:295-302
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: PARATYPHI C ; ENTERICA SEROVARS ; TYPHIMURIUM ; DIVERGENCE ; SEQUENCE ; STRAINS ; GENE ; ELECTROPHORESIS ; COLONIZATION ; CHOLERAESUIS
英文摘要:

Background: The genus Salmonella contains more than 2600 serovars. While most cause a self-limiting gastroenteritis, four serovars, S. Typhi, S. Paratyphi A, B and C, elicit typhoid, a potentially fatal systemic infection. Because of the prevalence in certain regions, such as South Asia, and the disease severity of typhoidal Salmonella infections, comprehensive studies are needed to elucidate the pathogenesis of diseases caused by these typhoidal serovars.

Results: We performed comparative genomic analyses on eight human typhoidal strains and 27 non-human typhoidal Salmonella strains to elucidate their evolutionary relationships and identify the genes specific to the four typhoidal serovars. Our results indicate that Salmonella may have an open pangenome. A core-genome based phylogeny demonstrated that divergence between S. Paratyphi A and S. Typhi took place not long ago and S. Paratyphi B shared a recent common ancestor with S. Paratyphi C. Of great interest, the divergence between S. Paratyphi B and S. Paratyphi C was shown to be more recent than that between S. Paratyphi A and S. Typhi. Alignment and comparisons of the genomes identified unique complements of protein families to each of the typhoidal serovars. Most of these protein families are phage related and some are candidate virulence factors. Importantly, we found 88 protein families specific to two to three of the four typhoidal serovars. All but two of the 88 genes are present in S. Typhi, with a few in the three paratyphoidal serovars but none in the non-human typhoidal serovars. Most of these genes are predicted to encode hypothetical proteins and some are known to code for virulence factors such as Vi polysaccharide related proteins.

Conclusions: By comprehensive genomic comparisons, we identified protein families specific to the human typhoidal serovars, which will greatly facilitate investigations on typhoid pathogenesis. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: NSFC31100134 ; NSFC81030029 ; 81271786
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000339954500037
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63234
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Comparative genomic analysis between typhoidal and non-typhoidal Salmonella serovars reveals typhoid-specific protein families.pdf(1421KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB, Canada
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100871, Peoples R China
3.Beijing Ctr Dis Control & Prevent, Inst Immunol, Beijing, Peoples R China
4.Harbin Med Univ, Genom Res Ctr, State Prov Key Labs Biomed Pharmaceut China, Harbin 150081, Peoples R China
5.Harbin Med Univ, HMU UCFM Ctr Infect & Genom, Harbin 150081, Peoples R China
6.Harbin Med Univ, Dept Biopharmaceut Sci, Fac Pharm, Harbin 150081, Peoples R China

Recommended Citation:
Zou, Qing-Hua,Li, Ren-Qing,Liu, Gui-Rong,et al. Comparative genomic analysis between typhoidal and non-typhoidal Salmonella serovars reveals typhoid-specific protein families[J]. INFECTION GENETICS AND EVOLUTION,2014,26(0):295-302.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zou, Qing-Hua]'s Articles
[Li, Ren-Qing]'s Articles
[Liu, Gui-Rong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zou, Qing-Hua]‘s Articles
[Li, Ren-Qing]‘s Articles
[Liu, Gui-Rong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace