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学科主题: 基础医学
题名:
Ventral Mesencephalon Astrocytes Are More Efficient Than Those of Other Regions in Inducing Dopaminergic Neurons Through Higher Expression Level of TGF-beta 3
作者: Li, Kairong1,2,3; Xue, Bing1,2,3; Wang, Yue1,2,3; Wang, Xuan4; Wang, Haomin1,2,3; Wang, Xiaomin1,2,3,4
关键词: Dopaminergic neurons ; Astrocytes ; Ventral mesencephalon ; Neurogenesis ; Transforming growth factor-beta 3
刊名: JOURNAL OF MOLECULAR NEUROSCIENCE
发表日期: 2009-03-01
DOI: 10.1007/s12031-008-9146-7
卷: 37, 期:3, 页:288-300
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: GROWTH-FACTOR-BETA ; NEURAL STEM-CELLS ; IN-VITRO ; NERVOUS-SYSTEM ; TGF-BETA ; DIFFERENTIATION ; NEUROGENESIS ; GLIA ; INDUCTION ; PRECURSORS
英文摘要:

Being supportive cells for neurons in the central nervous system, astrocytes have recently found to be associated with neurogenesis. Ventral mesencephalon (VM) astrocytes were also detected being instructive for VM dopaminergic (DA) neurogenesis, but the underling mechanisms are still unclear. This research is to figure out whether VM astrocytes are more efficient than those from other brain regions in inducing VM DA neurons from their precursors and whether transforming growth factor-beta s (TGF-beta s) are the underlying molecules. We found that, compared with astrocytes preparations from striatum and hippocampus, VM astrocytes preparations displayed markedly higher efficacy in inducing DA neurogenesis. Besides, they also expressed higher level of TGF-beta 3 than those of two other regions. When TGF-beta 3 gene expression in astrocytes preparations was inhibited by its antisense oligonucleotide, the induction of DA neurons decreased to a similar level among these three astrocytes preparations. Thus, our experiment indicates that VM astrocytes preparations which contained highly purified astrocytes are more efficient in inducing DA neurogenesis than those from other regions. Furthermore, it also suggests that the regional differences are regulated by different expression levels of TGF-beta 3 in those astrocytes preparations from different derivations.

语种: 英语
所属项目编号: 2006CB500700 ; 7021002
项目资助者: National Basic Research Program of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000262699000010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63238
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Neurosci PKU, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China
4.Capital Med Univ, Minist Educ, Dept Physiol, Key Lab Neurodegenerat Disorders, Beijing 100054, Peoples R China

Recommended Citation:
Li, Kairong,Xue, Bing,Wang, Yue,et al. Ventral Mesencephalon Astrocytes Are More Efficient Than Those of Other Regions in Inducing Dopaminergic Neurons Through Higher Expression Level of TGF-beta 3[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2009,37(3):288-300.
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