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学科主题: 公共卫生
题名:
The exposure metric choices have significant impact on the association between short-term exposure to outdoor particulate matter and changes in lung function: Findings from a panel study in chronic obstructive pulmonary disease patients
作者: Ni, Yang1; Wu, Shaowei1; Ji, Wenjing2; Chen, Yahong3; Zhao, Bin2; Shi, Shanshan2; Tu, Xingying1; Li, Hongyu1; Pan, Lu1; Deng, Furong1; Guo, Xinbiao1
关键词: Air pollution ; Particulate matter ; Exposure assessment ; Lung function ; Chronic obstructive pulmonary disease
刊名: SCIENCE OF THE TOTAL ENVIRONMENT
发表日期: 2016-01-15
DOI: 10.1016/j.scitotenv.2015.10.114
卷: 542, 页:264-270
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
关键词[WOS]: AIR-POLLUTION ; INDOOR EXPOSURE ; HEALTHY-ADULTS ; PARTICLES ; COPD ; CITIES ; TEMPERATURE ; PREVALENCE ; MORTALITY ; ORIGIN
英文摘要:

Background: The use of ambient air pollution data obtained from central air-monitoring stations as surrogates for participants′ exposures to outdoor air pollutants in previous studies may have introduced bias in the estimation of exposure-response associations.

Objectives: We investigated and compared the effects of short-term exposure to outdoor particulate matter (PMout) and outdoor-originated equivalent personal PM (PMeq) on lung function in chronic obstructive pulmonary disease (COPD) patients.

Methods: A total of 33 doctor-diagnosed stable COPD patients were recruited and repeatedly measured for lung function (totally 170 measurements) in 2013-2014. Daily PMout concentrations were obtained from central monitoring stations, and daily time-weighted average PMeq concentrations were estimated based on PMout over the study. Associations of PM with lung function were estimated using mixed-effects models.

Results: Interquartile range increases in PM2.5out (111.0 mu g/m(3), 5-day) and PM10out (112.0 mu g/m(3), 3-day) were associated with a 3.3% (95% confidence interval [CI]:-5.8%,-0.8%) reduction and a 2.1% (95% CI:-3.9%,-0.3%) reduction in forced vital capacity (FVC), respectively. Similar results were found for forced expiratory volume in 1 s (FEV1). An interquartile range increase in PM2.5eq (45.3 mu g/m(3), 3-day), but not PM10eq, was still associated with a 1.7% (95% CI: -3.3%, -0.1%) reduction in FVC.

Conclusions: Our study may provide a novel approach to assess the association of ambient PM with health observations with improved accuracy. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 20131000109 ; 81072267 ; 2006BAI19B06
项目资助者: Beijing Municipal Commission of Education ; National Natural Science Foundation of China ; National Key Technologies R&amp ; D Program of China
WOS记录号: WOS:000365602100028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63240
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Resp Dept, Beijing 100871, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
3.Tsinghua Univ, Sch Architecture, Dept Bldg Sci, Beijing 100084, Peoples R China

Recommended Citation:
Ni, Yang,Wu, Shaowei,Ji, Wenjing,et al. The exposure metric choices have significant impact on the association between short-term exposure to outdoor particulate matter and changes in lung function: Findings from a panel study in chronic obstructive pulmonary disease patients[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2016,542:264-270.
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