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In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron
Nie, F. L.1,2; Zheng, Y. F.1,2; Wei, S. C.2,3; Hu, C.4; Yang, G.4
刊名BIOMEDICAL MATERIALS
2010-12-01
DOI10.1088/1748-6041/5/6/065015
5期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]PORCINE CORONARY-ARTERIES ; MAGNESIUM ALLOYS ; STENTS ; BIOCOMPATIBILITY ; METAL ; IMPLANTATION ; BIOMATERIAL ; DEGRADATION ; TITANIUM ; CELLS
英文摘要

Bulk nanocrystalline pure iron rods were fabricated by the equal channel angular pressure (ECAP) technique up to eight passes. The microstructure and grain size distribution, natural immersion and electrochemical corrosion in simulated body fluid, cellular responses and hemocompatibility were investigated in this study. The results indicate that nanocrystalline pure iron after severe plastic deformation (SPD) would sustain durable span duration and exhibit much stronger corrosion resistance than that of the microcrystalline pure iron. The interaction of different cell lines reveals that the nanocrystalline pure iron stimulates better proliferation of fibroblast cells and preferable promotion of endothelialization, while inhibits effectively the viability of vascular smooth muscle cells (VSMCs). The burst of red cells and adhesion of the platelets were also substantially suppressed on contact with the nanocrystalline pure iron in blood circulation. A clear size-dependent behavior from the grain nature deduced by the gradual refinement microstructures was given and well-behaved in vitro biocompatibility of nanocrystalline pure iron was concluded.

语种英语
WOS记录号WOS:000286020800018
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63243
专题北京大学口腔医学院
作者单位1.Peking Univ, State Key Lab Turbulence & Complex Syst, Dept Adv Mat & Nanotechnol, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100083, Peoples R China
3.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
4.Cent Iron & Steel Res Inst, Inst Struct Mat, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Nie, F. L.,Zheng, Y. F.,Wei, S. C.,et al. In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron[J]. BIOMEDICAL MATERIALS,2010,5(6).
APA Nie, F. L.,Zheng, Y. F.,Wei, S. C.,Hu, C.,&Yang, G..(2010).In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron.BIOMEDICAL MATERIALS,5(6).
MLA Nie, F. L.,et al."In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron".BIOMEDICAL MATERIALS 5.6(2010).
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