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学科主题基础医学
Pharmacokinetics and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine in rats by high performance liquid chromatography-ion trap mass spectrometry
Wang, Shu-Mei; Dou, Gui-Fang; Li, Qiang; Liu, Ting; Meng, Zhi-Yun; Lou, Ya-Qing; Zhang, Guo-Liang
关键词3,4-dichlorophenyl-propenoyl-sec.-butylamine liquid chromatography-electrospray ionization-mass spectrometry pharmacokinetics metabolite
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2007-05-01
DOI10.1016/j.jchromb.2006.11.010
850期:1-2页:92-100
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PIPERINE ; EPILEPSY ; NMR
英文摘要

The pharmacokinetics (PK) and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylan ne (3,4-DCPB), a novel antiepileptic drug, were investigated after its oral administration to rats (100 mg/kg) by HPLC. The absorption and elimination of 3,4-DCPB were rapid. 3,4-DCPB was found to undergo extensive metabolism as the major route of elimination. Structures of the metabolites present in rat plasma were identified with liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS). It was concluded that 3,4-DCPB was involved in the multiple metabolic pathways (hydrolysis, dealkylation and oxidation) and the hydrolysis product, 3,4-dichloro-cinnamic acid (M I) appeared to be the major metabolite. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000246703500013
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63250
专题基础医学院_药理学系
作者单位1.Beijing Univ, Basic Med Sch, Dept Pharmacol, Beijing 100083, Peoples R China
2.Beijing Inst Transfus Med, Lab Drug Metab & Pharmacokinet, Beijing 100850, Peoples R China
推荐引用方式
GB/T 7714
Wang, Shu-Mei,Dou, Gui-Fang,Li, Qiang,et al. Pharmacokinetics and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine in rats by high performance liquid chromatography-ion trap mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,850(1-2):92-100.
APA Wang, Shu-Mei.,Dou, Gui-Fang.,Li, Qiang.,Liu, Ting.,Meng, Zhi-Yun.,...&Zhang, Guo-Liang.(2007).Pharmacokinetics and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine in rats by high performance liquid chromatography-ion trap mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,850(1-2),92-100.
MLA Wang, Shu-Mei,et al."Pharmacokinetics and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine in rats by high performance liquid chromatography-ion trap mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 850.1-2(2007):92-100.
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