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学科主题: 临床医学
题名:
Integrated Analysis of Multiple Gene Expression Profiling Datasets Revealed Novel Gene Signatures and Molecular Markers in Nasopharyngeal Carcinoma
作者: Huang, Chen1,2,3,5; Tang, Hailin1,2,3; Zhang, Wenling4; She, Xiaoling1,2,3; Liao, Qianjin1,2,3; Li, Xiaoling1,2,3; Wu, Minghua1,2,3; Li, Guiyuan1,2,3
刊名: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
发表日期: 2012
DOI: 10.1158/1055-9965.EPI-11-0593
卷: 21, 期:1, 页:166-175
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: COMPARATIVE GENOMIC HYBRIDIZATION ; EPSTEIN-BARR-VIRUS ; SOUTHERN CHINA ; PROGNOSTIC-SIGNIFICANCE ; CELL-PROLIFERATION ; TUMOR-SUPPRESSOR ; HUMAN CANCER ; PATHWAY ; GROWTH ; INHIBITOR
英文摘要:

Purpose: To identify the novel gene signatures and molecular markers of nasopharyngeal carcinoma (NPC) by integrated bioinformatics analysis of multiple gene expression profiling datasets.

Experimental Design: Seven published gene expression profiling studies and one of our unpublished works were reanalyzed to identify the common significantly dysregulated (CSD) genes in NPC. Overrepresentation analysis of cytogenetic bands, Gene Ontology (GO) categories, pathways were used to explore CSD genes functionally associated with carcinogenesis. The protein expressions of selected CSD genes were examined by immunohistochemistry on tissue microarrays, and the correlations of their expressions with clinical outcomes were evaluated.

Results: Using the criteria (genes reported deregulated in more than one study), a total of 962 genes were identified as the CSD genes in NPC. Four upregulated (BUB1B, CCND2, CENPF, and MAD2L1) and two downregulated (LTF and SLPI) genes were markedly reported in six studies. The enrichments of chromosome aberrations were 2q23, 2q31, 7p15, 12q15, 12q22, 18q11, and 18q12 in upregulated genes and 14q32 and 16q13 in downregulated genes. The activated GO categories and pathways related to proliferation, adhesion, invasion, and downregulated immune response had been functionally associated with NPC. SLPI significantly downregulated in nasopharyngeal adenocarcinoma. Furthermore, the high expression of BUB1B or CENPF was associated with poor overall survival of patients.

Conclusion: It was first clearly identified the dysregulated expression of BUB1B and SLPI in NPC tissues.

Impact: Further studies of the CSD genes as gene signatures and molecular markers of NPC might improve the understanding of the disease and identify new therapeutic targets. Cancer Epidemiol Biomarkers Prev; 21(1); 166-75. (C) 2011 AACR.

语种: 英语
所属项目编号: 10JJ7003 ; 11JJ1013
项目资助者: Hunan Province Natural Sciences Foundations
WOS记录号: WOS:000299051500017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63253
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Cent S Univ, Canc Res Inst, Dis Genome Res Ctr, Changsha 410078, Hunan, Peoples R China
2.Minist Educ, Key Lab Carcinogenesis & Canc Invas, Beijing, Peoples R China
3.Minist Hlth, Key Lab Carcinogenesis, Beijing, Peoples R China
4.Cent S Univ, Xiangya Sch Med, Dept Med Lab Sci, Changsha 410078, Hunan, Peoples R China
5.Peking Univ, Hosp 3, Med Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Huang, Chen,Tang, Hailin,Zhang, Wenling,et al. Integrated Analysis of Multiple Gene Expression Profiling Datasets Revealed Novel Gene Signatures and Molecular Markers in Nasopharyngeal Carcinoma[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2012,21(1):166-175.
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